Department of Clinical Laboratory, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, PR China.
Exp Mol Med. 2021 Nov;53(11):1669-1673. doi: 10.1038/s12276-021-00699-4. Epub 2021 Nov 24.
Exosomes play a vital role in cell-cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are important regulators in cancer development and are involved in multiple processes, including cancer cell proliferation, angiogenesis, metastasis, drug resistance, and immunomodulation. Changes in the levels of exosomal lncRNAs often appear with the occurrence and development of cancer. Therefore, exosomal lncRNAs can be used as biomarkers for cancer diagnosis and prognosis. Exosomal lncRNAs can also indicate the treatment response of patients receiving chemotherapy. Moreover, exosomal lncRNAs are potential therapeutic targets for cancer treatment. In this review, we summarize the role of exosomal lncRNAs in cancer biology as well as in clinical management. A more comprehensive and in-depth understanding of the role of exosomal lncRNAs in cancer may help us better understand the mechanism of cancer development and clinically manage cancer patients.
外泌体在肿瘤微环境中的细胞间通讯中起着至关重要的作用。外泌体长链非编码 RNA（lncRNA）是癌症发展中的重要调节因子，参与包括癌细胞增殖、血管生成、转移、耐药和免疫调节在内的多个过程。外泌体 lncRNA 水平的变化通常伴随着癌症的发生和发展而出现。因此，外泌体 lncRNA 可作为癌症诊断和预后的生物标志物。外泌体 lncRNA 还可以指示接受化疗的患者的治疗反应。此外，外泌体 lncRNA 是癌症治疗的潜在治疗靶点。在这篇综述中，我们总结了外泌体 lncRNA 在癌症生物学以及临床管理中的作用。更全面和深入地了解外泌体 lncRNA 在癌症中的作用可能有助于我们更好地理解癌症发展的机制，并对癌症患者进行临床管理。
