• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血管内图像引导下对肿瘤引流静脉进行采样可提供丰富的肿瘤生物标志物来源。

Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers.

作者信息

Tamrazi Anobel, Sundaresan Srividya, Gulati Aishwarya, Tan Frederick J, Wadhwa Vibhor, Bartlett Bjarne R, Diaz Luis A Jr

机构信息

Division of Vascular and Interventional Radiology, Palo Alto Medical Foundation, Redwood City, CA, United States.

Department of Clinical Research, Dignity Health, Sequoia Hospital, Redwood City, CA, United States.

出版信息

Front Oncol. 2023 Mar 17;13:916196. doi: 10.3389/fonc.2023.916196. eCollection 2023.

DOI:10.3389/fonc.2023.916196
PMID:37007151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10064007/
Abstract

INTRODUCTION

Circulating tumor-derived biomarkers can potentially impact cancer management throughout the continuum of care. This small exploratory study aimed to assess the relative levels of such biomarkers in the tumor-draining vascular beds in patients with solid tumors compared to levels in their peripheral veins.

METHODS

Using an endovascular image-guided approach, we obtained blood samples from peripheral veins and other vascular compartments-including the most proximal venous drainage from solid tumors-from a set of nine oncology patients with various primary and metastatic malignancies. We then interrogated these samples for a panel of oncological biomarkers, including circulating tumor cells (CTCs), exosome-derived microRNAs (miRNAs), circulating tumor DNA (ctDNA) mutations, and certain cancer-related proteins/biochemical markers.

RESULTS

We found substantially higher levels of CTCs, certain miRNAs, and specific ctDNA mutations in samples from vascular beds closer to the tumor compared with those from peripheral veins and also noted that some of these signals were altered by treatment procedures.

DISCUSSION

Our results indicate that tumor-proximal venous samples are highly enriched for some oncological biomarkers and may allow for more robust molecular analysis than peripheral vein samples.

摘要

引言

循环肿瘤衍生生物标志物可能会在整个连续护理过程中对癌症管理产生影响。这项小型探索性研究旨在评估实体瘤患者肿瘤引流血管床中此类生物标志物的相对水平，并与外周静脉中的水平进行比较。

方法

采用血管内图像引导方法，我们从一组9名患有各种原发性和转移性恶性肿瘤的肿瘤患者的外周静脉和其他血管腔室（包括实体瘤最近端的静脉引流）采集血样。然后，我们对这些样本进行了一组肿瘤生物标志物检测，包括循环肿瘤细胞（CTC）、外泌体衍生的微小RNA（miRNA）、循环肿瘤DNA（ctDNA）突变以及某些癌症相关蛋白/生化标志物。

结果

我们发现，与外周静脉样本相比，来自更接近肿瘤的血管床样本中的CTC、某些miRNA和特定ctDNA突变水平显著更高，并且还注意到其中一些信号会因治疗程序而改变。

讨论

我们的结果表明，肿瘤近端静脉样本中某些肿瘤生物标志物高度富集，与外周静脉样本相比，可能允许进行更强大的分子分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/8c27a1760f40/fonc-13-916196-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/3f31706fa465/fonc-13-916196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/2391c39b28d9/fonc-13-916196-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/e21f382c14f1/fonc-13-916196-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/ea5f9a9edca3/fonc-13-916196-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/d339e408d1f4/fonc-13-916196-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/ed37cc36cd31/fonc-13-916196-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/dfa1e6185477/fonc-13-916196-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/164c1029ebb8/fonc-13-916196-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/d9e912405af2/fonc-13-916196-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/044ae0c9e6ff/fonc-13-916196-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/1f4782f4a9af/fonc-13-916196-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/8c27a1760f40/fonc-13-916196-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/3f31706fa465/fonc-13-916196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/2391c39b28d9/fonc-13-916196-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/e21f382c14f1/fonc-13-916196-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/ea5f9a9edca3/fonc-13-916196-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/d339e408d1f4/fonc-13-916196-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/ed37cc36cd31/fonc-13-916196-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/dfa1e6185477/fonc-13-916196-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/164c1029ebb8/fonc-13-916196-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/d9e912405af2/fonc-13-916196-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/044ae0c9e6ff/fonc-13-916196-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/1f4782f4a9af/fonc-13-916196-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afb2/10064007/8c27a1760f40/fonc-13-916196-g012.jpg

相似文献

1
Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers.血管内图像引导下对肿瘤引流静脉进行采样可提供丰富的肿瘤生物标志物来源。
Front Oncol. 2023 Mar 17;13:916196. doi: 10.3389/fonc.2023.916196. eCollection 2023.
2
Liquid biopsy, a paradigm shift in oncology: what interventional radiologists should know.液体活检：肿瘤学的范式转变：介入放射科医生应该知道什么。
Eur Radiol. 2020 Aug;30(8):4496-4503. doi: 10.1007/s00330-020-06700-4. Epub 2020 Mar 19.
3
Using Liquid Biopsy in the Treatment of Patient with OS.液体活检在 OS 患者治疗中的应用。
Adv Exp Med Biol. 2020;1257:95-105. doi: 10.1007/978-3-030-43032-0_9.
4
Methylation: A Liquid Biopsy-Based Epigenetic Assay for the Follow-up of Patients with Metastatic Breast Cancer Receiving Endocrine Treatment.甲基化：一种基于液体活检的表观遗传学检测，用于接受内分泌治疗的转移性乳腺癌患者的随访。
Clin Cancer Res. 2018 Mar 15;24(6):1500-1510. doi: 10.1158/1078-0432.CCR-17-1181. Epub 2017 Dec 28.
5
Clinical Implications of Circulating Tumor Cells in Patients with Esophageal Squamous Cell Carcinoma: Cancer-Draining Blood Versus Peripheral Blood.食管鳞状细胞癌患者循环肿瘤细胞的临床意义：引流癌组织血液与外周血的比较
Cancers (Basel). 2024 Aug 22;16(16):2921. doi: 10.3390/cancers16162921.
6
PIK3CA hotspot mutations in circulating tumor cells and paired circulating tumor DNA in breast cancer: a direct comparison study.循环肿瘤细胞和配对循环肿瘤 DNA 中乳腺癌 PIK3CA 热点突变的直接比较研究。
Mol Oncol. 2019 Dec;13(12):2515-2530. doi: 10.1002/1878-0261.12540. Epub 2019 Sep 30.
7
The potential of liquid biopsy in the management of cancer patients.液体活检在癌症患者管理中的应用潜力。
Semin Cancer Biol. 2022 Sep;84:69-79. doi: 10.1016/j.semcancer.2022.03.013. Epub 2022 Mar 21.
8
Incorporating MicroRNA into Molecular Phenotypes of Circulating Tumor Cells Enhances the Prognostic Accuracy for Patients with Metastatic Breast Cancer.将 microRNA 纳入循环肿瘤细胞的分子表型可提高转移性乳腺癌患者的预后准确性。
Oncologist. 2019 Nov;24(11):e1044-e1054. doi: 10.1634/theoncologist.2018-0697. Epub 2019 Jul 12.
9
Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancer.通过无标记平台捕获的循环肿瘤细胞中KRAS、BRAF和PIK3CA突变的计数及靶向分析：与转移性结直肠癌中的循环肿瘤DNA和组织的比较
Oncotarget. 2016 Dec 20;7(51):85349-85364. doi: 10.18632/oncotarget.13350.
10
Association of a novel circulating tumor DNA next-generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer.新型循环肿瘤 DNA 下一代测序平台与转移性乳腺癌中循环肿瘤细胞 (CTC) 和 CTC 簇的关联。
Breast Cancer Res. 2019 Dec 4;21(1):137. doi: 10.1186/s13058-019-1229-6.

引用本文的文献

1
Targeted liquid biopsy for brain tumors.针对脑肿瘤的靶向液体活检。
J Liq Biopsy. 2024 Oct 12;6:100170. doi: 10.1016/j.jlb.2024.100170. eCollection 2024 Dec.
2
Circulating miRNA Expression Is Inversely Correlated with Tumor Tissue or Sentinel Lymph Nodes in Estrogen Receptor-Positive Early Breast Cancer Patients.循环 miRNA 表达与雌激素受体阳性早期乳腺癌患者的肿瘤组织或前哨淋巴结呈负相关。
Int J Mol Sci. 2023 Aug 27;24(17):13293. doi: 10.3390/ijms241713293.

本文引用的文献

1
Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance.循环肿瘤核酸：生物学、释放机制和临床相关性。
Mol Cancer. 2023 Jan 21;22(1):15. doi: 10.1186/s12943-022-01710-w.
2
Fragment size and dynamics of EGFR-mutated tumor-derived DNA provide prognostic information regarding EGFR-TKI efficacy in patients with EGFR-mutated NSCLC.肿瘤 EGFR 突变衍生 DNA 的片段大小和动态可提供关于 EGFR-TKI 治疗 EGFR 突变型 NSCLC 患者疗效的预后信息。
Sci Rep. 2022 Aug 8;12(1):13544. doi: 10.1038/s41598-022-17848-y.
3
Complementing Tissue Testing With Plasma Mutation Profiling Improves Therapeutic Decision-Making for Patients With Lung Cancer.
血浆突变谱分析辅助组织检测可改善肺癌患者的治疗决策。
Front Med (Lausanne). 2022 Feb 11;9:758464. doi: 10.3389/fmed.2022.758464. eCollection 2022.
4
Circulating Tumor DNA and Minimal Residual Disease (MRD) in Solid Tumors: Current Horizons and Future Perspectives.实体瘤中的循环肿瘤DNA与微小残留病（MRD）：当前视野与未来展望
Front Oncol. 2021 Nov 18;11:763790. doi: 10.3389/fonc.2021.763790. eCollection 2021.
5
Clinical Outcomes for Plasma-Based Comprehensive Genomic Profiling Versus Standard-of-Care Tissue Testing in Advanced Non-Small Cell Lung Cancer.基于血浆的全面基因组分析与标准护理组织检测在晚期非小细胞肺癌中的临床结局比较。
Clin Lung Cancer. 2022 Jan;23(1):72-81. doi: 10.1016/j.cllc.2021.10.001. Epub 2021 Oct 10.
6
Liquid Biopsy, the hype vs. hope in molecular and clinical oncology.液体活检：分子与临床肿瘤学中的 hype 与 hope。
Semin Oncol. 2021 Jun;48(3):259-267. doi: 10.1053/j.seminoncol.2021.06.002. Epub 2021 Jul 14.
7
Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma.通过单细胞 RNA-seq 解析肝细胞癌中 CTCs 的空间异质性和免疫逃逸机制。
Nat Commun. 2021 Jul 2;12(1):4091. doi: 10.1038/s41467-021-24386-0.
8
Liquid Biopsy: From Discovery to Clinical Application.液体活检：从发现到临床应用。
Cancer Discov. 2021 Apr;11(4):858-873. doi: 10.1158/2159-8290.CD-20-1311.
9
Beyond Standard Practice in Liquid Biopsy: Selective Venous Sampling.超越液体活检的标准实践：选择性静脉采样。
J Vasc Interv Radiol. 2021 May;32(5):668-671. doi: 10.1016/j.jvir.2021.02.010. Epub 2021 Feb 20.
10
Liquid biopsy enters the clinic - implementation issues and future challenges.液体活检进入临床——实施问题与未来挑战。
Nat Rev Clin Oncol. 2021 May;18(5):297-312. doi: 10.1038/s41571-020-00457-x. Epub 2021 Jan 20.