Kumari Sangeeta, Singh Kalpana, Tiwary Bhawana, Kumari Shubhanti, Nishat Huma
Reproductive Medicine, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Cureus. 2023 Feb 27;15(2):e35546. doi: 10.7759/cureus.35546. eCollection 2023 Feb.
Background Lifestyle habits and demographic characteristics are strongly associated with sperm and oocyte quality and are important co-variates in fertility. However, their effect on the pre-implantation embryo quality in fertilization (IVF) has not been explored widely. The present retrospective study aimed to explore the effect of maternal and paternal demographic and lifestyle factors on the pre-implantation embryo quality in IVF. Methodology Women in the age group of 21 to 40 years undergoing IVF (n=105) in the Department of Reproductive Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, and their partners were recruited in the study. Maternal and paternal charts were reviewed, and the demographic, lifestyle habit related data, and data related to oocyte retrieval, oocyte quality, and embryo quality were retrieved in a predesigned spreadsheet. Appropriate statistical analysis was conducted using SPSS Version 21 to evaluate the association of the studied maternal and paternal factors with oocyte and embryo quality. P-values less than 0.05 were considered to be significant. Results Maternal factors such as tubal blockage (p=0.02) and residence in an industrial locality (p=0.001) were found to be significantly associated with the quality of oocytes. None of the maternal factors studied were associated with embryo quality; however, day 3 and day 5 embryo quality was significantly associated with educational status of the male partners (p=0.02), smoking (p=0.05), and chewing tobacco (p=0.01). Day 5 embryo quality was also associated with residence in an industrial locality of the male partners (p=0.04). Conclusions Paternal lifestyle habits such as smoking, chewing tobacco, and demographic characteristics such as education and proximity to an industrial area were all related to poor embryo quality. Maternal factors such as tubal blockage and residence of industrial locality were found to be significantly associated with the quality of oocytes.
背景 生活方式习惯和人口统计学特征与精子和卵母细胞质量密切相关，并且是生育能力的重要协变量。然而，它们对体外受精（IVF）中植入前胚胎质量的影响尚未得到广泛研究。本回顾性研究旨在探讨父母的人口统计学和生活方式因素对IVF中植入前胚胎质量的影响。
方法 在比哈尔邦巴特那英迪拉甘地医学科学研究所生殖医学科接受IVF治疗（n = 105）的21至40岁年龄组女性及其伴侣被纳入研究。查阅了父母的病历，并在预先设计的电子表格中检索了人口统计学、生活方式习惯相关数据以及与卵母细胞采集、卵母细胞质量和胚胎质量相关的数据。使用SPSS 21版进行了适当的统计分析，以评估所研究的父母因素与卵母细胞和胚胎质量之间的关联。P值小于0.05被认为具有统计学意义。
结果 发现诸如输卵管阻塞（p = 0.02）和居住在工业区（p = 0.001）等母亲因素与卵母细胞质量显著相关。所研究的母亲因素均与胚胎质量无关；然而，第3天和第5天的胚胎质量与男性伴侣的教育程度（p = 0.02）、吸烟（p = 0.05）和嚼烟（p = 0.01）显著相关。第5天的胚胎质量也与男性伴侣居住在工业区有关（p = 0.04）。
结论 父亲的生活方式习惯如吸烟、嚼烟以及人口统计学特征如教育程度和靠近工业区都与胚胎质量差有关。发现诸如输卵管阻塞和居住在工业区等母亲因素与卵母细胞质量显著相关。
