Department of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
BMJ Open. 2020 Nov 26;10(11):e038837. doi: 10.1136/bmjopen-2020-038837.
We investigated whether lifestyle affects assisted reproduction technology (ART) outcomes.
Cohort study.
Italian fertility unit.
From September 2014 to December 2016, women from couples presenting for evaluation and eligible for ART were invited to participate. Information on alcohol intake, current smoking and leisure physical activity (PA) during the year before the interview was collected, using a structured questionnaire. We considered the ART outcomes of the cycle immediately following the interview.
The primary outcome measure was cumulative pregnancy rate per retrieval. Secondary measures were number of retrieved oocytes, embryo transfer and live birth.
In 492 women undergoing an ART cycle, 427 (86.8%) underwent embryo transfer, 157 (31.9%) had at least one clinical pregnancy and 121 (24.6%) had live birth. The cumulative pregnancy rate per retrieval was 33.3% (95% CI 28.5% to 38.7%). In women in the third tertile of alcohol intake, adjusted relative risk was 0.97 (95% CI 0.87 to 1.08), 0.90 (95% CI 0.62 to 1.30) and 0.89 (95% CI 0.57 to 1.37) for embryo transfer, clinical pregnancy and live birth, respectively. The corresponding figures in women currently smoking more than 5 cigarettes/day were 1.00 (95% CI 0.88 to 1.16), 0.94 (95% CI 0.60 to 1.48) and 1.14 (95% CI 0.68 to 1.90), and in women with PA ≥5 hours/week were 0.93 (95% CI 0.79 to 1.08), 0.44 (95% CI 0.22 to 0.90) and 0.48 (95% CI 0.22 to 1.05), respectively.
There were no significant differences in in vitro fertilisation outcomes among women who used alcohol or tobacco in the year prior to treatment. Conservatively, all women should be advised to limit substance abuse. Moreover, our study suggested that maintaining a moderate, but not high, level of PA could be beneficial.
研究生活方式是否会影响辅助生殖技术（ART）的结果。
队列研究。
意大利生育单位。
2014 年 9 月至 2016 年 12 月，邀请前来评估并符合 ART 条件的夫妇中的女性参加。使用结构化问卷收集了她们在接受采访前一年的饮酒量、当前吸烟和休闲体育活动（PA）的信息。我们考虑了采访后立即进行的 ART 周期的结果。
主要结果测量是每次检索的累积妊娠率。次要结果测量是取回的卵母细胞数量、胚胎移植和活产。
在 492 名接受 ART 周期的女性中，427 名（86.8%）进行了胚胎移植，157 名（31.9%）至少有一次临床妊娠，121 名（24.6%）活产。每次检索的累积妊娠率为 33.3%（95%CI 28.5%至 38.7%）。在饮酒量处于第三三分位的女性中，调整后的相对风险分别为 0.97（95%CI 0.87 至 1.08）、0.90（95%CI 0.62 至 1.30）和 0.89（95%CI 0.57 至 1.37），用于胚胎移植、临床妊娠和活产。目前每天吸烟超过 5 支的女性的相应数字分别为 1.00（95%CI 0.88 至 1.16）、0.94（95%CI 0.60 至 1.48）和 1.14（95%CI 0.68 至 1.90），而每周 PA≥5 小时的女性分别为 0.93（95%CI 0.79 至 1.08）、0.44（95%CI 0.22 至 0.90）和 0.48（95%CI 0.22 至 1.05）。
在治疗前一年内使用酒精或烟草的女性中，体外受精结果没有显著差异。保守地说，应该建议所有女性限制滥用物质。此外，我们的研究表明，保持适度但不过度的 PA 水平可能是有益的。
