血清甘油三酯水平与急性高甘油三酯血症性胰腺炎患者的复发相关。
Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis.
作者信息
Guan Langyi, Ding Ling, Wan Jianhua, Xia Liang, He Wenhua, Xiong Huifang, Luo Lingyu, Lu Nonghua, Zhu Yin
机构信息
Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
出版信息
Front Med (Lausanne). 2023 Mar 15;10:1079637. doi: 10.3389/fmed.2023.1079637. eCollection 2023.
AIM
To analyze the clinical profile of patients with acute hypertriglyceridemic pancreatitis (HTGP) and explore risk factors for recurrence.
METHODS
A retrospective observational study was conducted in patients who experienced an attack of HTGP for the first time. Patients were followed until the recurrence of acute pancreatitis (AP) or 1 year. The detailed clinical profile was compared between patients with or without recurrence. Multivariate logistic regression analysis was conducted to explore independent risk factors for recurrence.
RESULTS
A total of 108 HTGP patients were included in this study with 73.1% being male, and the median age being 37 (interquartile range, IQR, 30.3-44.8) years. Recurrence occurred in 70 patients (64.8%). Compared with the nonrecurrent group, serum triglyceride (TG) levels before discharge [4.1 (2.8,6.3) mmol/L vs. 2.9 (2.2,4.2) mmol/L; = 0.002], at 1 month [3.7 (2.3,9.7) mmol/L vs. 2.0 (1.4,2.7) mmol/L; = 0.001], at 6 months [6.1 (3.1,13.1) mmol/L vs. 2.5 (1.1,3.5) mmol/L; = 0.003] and 12 months [9.6 (3.5,20.0) mmol/L vs. 2.7 (1.6,5.5) mmol/L; = 0.001] after discharge were higher in the recurrent group. Poor control of TG levels (TG > 3.1 mmol/l) at the 1-month follow-up after discharge and a high Charlson's Comorbidity Index score (≥ 2 points) increased the risk of recurrence of HTGP.
CONCLUSION
High TG levels during follow-up and Charlson's Comorbidity Index score were independently associated with recurrence in patients with HTGP.
目的
分析急性高甘油三酯血症性胰腺炎（HTGP）患者的临床特征，并探讨复发的危险因素。
方法
对首次发作HTGP的患者进行一项回顾性观察研究。对患者进行随访直至急性胰腺炎（AP）复发或1年。比较有或无复发患者的详细临床特征。进行多因素逻辑回归分析以探讨复发的独立危险因素。
结果
本研究共纳入108例HTGP患者，其中73.1%为男性，中位年龄为37岁（四分位间距，IQR，30.3 - 44.8）。70例患者（64.8%）出现复发。与未复发组相比，复发组出院前血清甘油三酯（TG）水平[4.1（2.8，6.3）mmol/L对2.9（2.2，4.2）mmol/L；P = 0.002]、出院后1个月[3.7（2.3，9.7）mmol/L对2.0（1.4，2.7）mmol/L；P = 0.001]、6个月[6.1（3.1，13.1）mmol/L对2.5（1.1，3.5）mmol/L；P = 0.003]和12个月[9.6（3.5，20.0）mmol/L对2.7（1.6，5.5）mmol/L；P = 0.001]更高。出院后1个月随访时TG水平控制不佳（TG > 3.1 mmol/l）和高Charlson合并症指数评分（≥2分）增加了HTGP复发的风险。
结论
随访期间高TG水平和Charlson合并症指数评分与HTGP患者的复发独立相关。
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