Basavarajappa Girish Meravanige, Priyanka K M, Goudanavar Prakash, Narasimha Lakshmi G, Naveen N Raghavendra, Gowthami Buduru, Fattepur Santosh, Shiroorkar Predeepkumar Narayanappa, Nagaraja Sreeharsha, Telsang Mallikarjun, Jasthi Veeriah Chowdary, Sreenivasalu Pavan Kumar Pavagada
Department of Biomedical Sciences, College of Medicine, King Faisal University, Al Ahsa, Saudi Arabia.
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G.Nagar, Karnataka, India.
Des Monomers Polym. 2023 Mar 30;26(1):106-116. doi: 10.1080/15685551.2023.2194176. eCollection 2023.
Polymers are a fundamental part of numerous industries and can be conjugated with many other materials and components to have a vast array of products. Biomaterials have been extensively studied for their application in pharmaceutical formulation development, tissue engineering, and biomedical areas. However, the native form of many polymers has limitations concerning microbial contamination, susceptibility, solubility, and stability. Chemical or physical modifications can overcome these limitations by tailoring the properties of polymers to meet several requirements. The polymer modifications are interdisciplinary, cutting across conventional materials, physics, biology, chemistry, medicine, and engineering limitations. Microwave irradiation has become a well-established technique for a few decades to drive and promote chemical modification reactions. This technique allows ease of temperature and power control to perform the synthesis protocols efficiently. Additionally, microwave irradiation contributes to green and sustainable chemistry. In this contribution, microwave-assisted polymer modifications were described with a special focus on their application in developing several novel dosage forms.
聚合物是众多行业的基础组成部分，并且可以与许多其他材料和成分结合，从而拥有大量的产品。生物材料因其在药物制剂开发、组织工程和生物医学领域的应用而受到广泛研究。然而，许多聚合物的天然形式在微生物污染、敏感性、溶解性和稳定性方面存在局限性。化学或物理修饰可以通过调整聚合物的性质以满足多种要求来克服这些局限性。聚合物修饰是跨学科的，跨越了传统材料、物理、生物学、化学、医学和工程学的限制。几十年来，微波辐射已成为一种成熟的技术，用于驱动和促进化学修饰反应。该技术便于温度和功率控制，从而有效地执行合成方案。此外，微波辐射有助于绿色和可持续化学。在本论文中，描述了微波辅助的聚合物修饰，特别关注其在开发几种新型剂型中的应用。
