School of Biological Sciences, National Institute of Science Education and Research, Institute of Physics Campus, Sainik School, Sachivalaya marg, Bhubaneswar-751005, India.
Mol Pharm. 2012 Sep 4;9(9):2365-79. doi: 10.1021/mp3001952. Epub 2012 Aug 14.
Biodegradable polymers provided the opportunity to explore beyond conventional drug delivery and turned out to be the focus of current drug delivery. In spite of availability of diverse class of polymers, several of these polymers lack important physicochemical and biological properties, limiting their widespread application in pharmaceutical drug delivery. However, most polymers in the form of blends, copolymers and functionally modified polymers have exhibited their applicability to overcome specific limitations and to produce novel and/or functionalized formulations for drug delivery as well as tissue engineering. This review aims to provide the need of polymeric modification, approaches adopted to modify and their scope. Special emphasis has been given to synthetic polyester PCL, as it is widely demonstrated in its modified form to overcome its problem of hydrophobicity and much slower degradation over the past decade. Past studies show a significantly higher utility of modified form of PCL in comparison to its native form. From the statistical analysis of these modifications and the formulations prepared, we present a basic understanding of the impact of selective modifications on the formulation design. In conclusion, we remark that a thorough understanding of the polymer and its modification has a huge potential to be the future trend for drug delivery and tissue engineering applications.
可生物降解聚合物提供了超越传统药物传递的机会，结果成为当前药物传递的焦点。尽管有多种类型的聚合物可供选择，但其中一些聚合物缺乏重要的物理化学和生物学特性，限制了它们在药物传递等制药领域的广泛应用。然而，大多数聚合物以共混物、共聚物和功能改性聚合物的形式存在，它们表现出了适用性，能够克服特定的限制，并为药物传递以及组织工程生产新型和/或功能化的制剂。本综述旨在提供聚合物改性的必要性、所采用的方法及其范围。特别强调了合成聚酯聚己内酯（PCL），因为在过去十年中，它以改性形式广泛展示，以克服其疏水性和降解速度较慢的问题。过去的研究表明，与天然形式相比，改性形式的 PCL 具有更高的实用性。从对这些改性和制剂的统计学分析中，我们对选择性改性对制剂设计的影响有了基本的了解。总之，我们注意到，对聚合物及其改性的深入了解具有成为药物传递和组织工程应用未来趋势的巨大潜力。
