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一名骑马者的头痛

Headaches in a Horseback Rider.

作者信息

Hunter Nicole, Kostowniak Christian, Hamayel Abdallah, Bliss Aaron, Lakin Hunter, Tan Josenia, Proia Laurie

机构信息

Department of Internal Medicine, Rochester Regional Health Unity Hospital, Rochester, New York, USA.

Department of Medicine, Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania, USA.

出版信息

Open Forum Infect Dis. 2023 Mar 20;10(3):ofad145. doi: 10.1093/ofid/ofad145. eCollection 2023 Mar.

DOI:10.1093/ofid/ofad145
PMID:37008570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10061565/
Abstract

An immunocompetent woman presented with headaches. She previouslyworked at a farm in upstate New York. Brain MRI noted pituitary enlargement and neurosurgerypursued trans-sphenoidal pituitary biopsy. Histopathology revealed ill-defined granulomaswith clusters of yeast, consistent with Histoplasma.

摘要

一名免疫功能正常的女性出现头痛症状。她之前在纽约州北部的一个农场工作。脑部磁共振成像（MRI）显示垂体肿大，神经外科进行了经蝶窦垂体活检。组织病理学检查发现边界不清的肉芽肿，伴有酵母簇，符合组织胞浆菌病表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f1/10061565/98b8f5302264/ofad145f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f1/10061565/780f55d1d05b/ofad145f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f1/10061565/98b8f5302264/ofad145f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f1/10061565/780f55d1d05b/ofad145f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f1/10061565/98b8f5302264/ofad145f2.jpg

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本文引用的文献

1
The Geographic Distribution of Dimorphic Mycoses in the United States for the Modern Era.现代美国二相性真菌病的地理分布。
Clin Infect Dis. 2023 Apr 3;76(7):1295-1301. doi: 10.1093/cid/ciac882.
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Ibrexafungerp, a Novel Triterpenoid Antifungal in Development for the Treatment of Mold Infections.依布康唑，一种正在研发用于治疗霉菌感染的新型三萜类抗真菌药物。
J Fungi (Basel). 2022 Oct 25;8(11):1121. doi: 10.3390/jof8111121.
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The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin.抗真菌药物管线上的药物：福沙那韦、依柏西普、奥洛福康唑、泊沙康唑和瑞他康唑。
Drugs. 2021 Oct;81(15):1703-1729. doi: 10.1007/s40265-021-01611-0. Epub 2021 Oct 9.
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Histoplasmosis.组织胞浆菌病。
Infect Dis Clin North Am. 2021 Jun;35(2):471-491. doi: 10.1016/j.idc.2021.03.011.
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Fosmanogepix: A Review of the First-in-Class Broad Spectrum Agent for the Treatment of Invasive Fungal Infections.福沙诺吉哌：用于治疗侵袭性真菌感染的一流广谱药物综述
J Fungi (Basel). 2020 Oct 22;6(4):239. doi: 10.3390/jof6040239.
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HIV-Associated Histoplasmosis: Current Perspectives.HIV 相关组织胞浆菌病：当前观点
HIV AIDS (Auckl). 2020 Mar 19;12:113-125. doi: 10.2147/HIV.S185631. eCollection 2020.
7
Current Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes.当前关于组织胞浆菌病综合征的流行病学、诊断和治疗的概念。
Semin Respir Crit Care Med. 2020 Feb;41(1):13-30. doi: 10.1055/s-0039-1698429. Epub 2020 Jan 30.
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Isavuconazole for the treatment of patients with invasive fungal diseases involving the central nervous system.伊曲康唑治疗涉及中枢神经系统的侵袭性真菌病患者。
Med Mycol. 2020 Jun 1;58(4):417-424. doi: 10.1093/mmy/myz103.
9
SCY-078, a Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections during Mass Balance Studies with Intravenous and Oral [C]SCY-078 in Albino and Pigmented Rats.在静脉内和口服 [C]SCY-078 于白化和色素沉着大鼠的体内物质平衡研究中，新型杀真菌剂 SCY-078 显示向与真菌感染相关的组织分布。
Antimicrob Agents Chemother. 2019 Jan 29;63(2). doi: 10.1128/AAC.02119-18. Print 2019 Feb.
10
Central nervous system histoplasmosis: Multicenter retrospective study on clinical features, diagnostic approach and outcome of treatment.中枢神经系统组织胞浆菌病：关于临床特征、诊断方法及治疗结果的多中心回顾性研究
Medicine (Baltimore). 2018 Mar;97(13):e0245. doi: 10.1097/MD.0000000000010245.