利用光学相干断层扫描血管造影术评估科茨病黄斑结节的微血管系统：3例报告
An Evaluation of the Microvasculature of Macular Nodules in Coats Disease Using Optical Coherence Tomography Angiography: A Report of 3 Cases.
作者信息
Ong Sally S, Hsu S Tammy, Ponugoti Arathi, Toth Cynthia A, Vajzovic Lejla
机构信息
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
出版信息
J Vitreoretin Dis. 2021 Feb 10;5(5):431-437. doi: 10.1177/2474126420983679. eCollection 2021 Sep-Oct.
PURPOSE
This work aimed to examine the microvasculature of macular fibrosis in Coats disease.
METHODS
Three boys (aged 3, 4, and 6 years) with Coats disease (stages 2B to 3A2) and macular fibrotic nodules were imaged using optical coherence tomography angiography (OCTA) on the Spectralis spectral-domain OCT tabletop and investigational portable Spectralis Flex module (version 6.9, Heidelberg Engineering).
RESULTS
In 2 eyes, a neovascular complex was observed in the avascular slab on OCTA. This neovascular complex had vessels connected to diving vessels from the superficial vascular complex that traveled through the deep vascular complex to the avascular complex. In the third eye, no neovascular complex was observed on OCTA at presentation, but on subsequent examinations fluorescein leakage was observed and cross-sectional OCTA further confirmed the presence of angiographic flow in the nodule.
CONCLUSIONS
OCTA demonstrates the presence of type 3 neovascularization in fibrotic nodules in Coats disease.
目的
本研究旨在检查科茨病黄斑纤维化的微血管系统。
方法
对3名患有科茨病（2B至3A2期）且有黄斑纤维化结节的男孩（年龄分别为3岁、4岁和6岁），使用Spectralis光谱域光学相干断层扫描血管造影（OCTA）设备在Spectralis光谱域OCT台式机及研究性便携式Spectralis Flex模块（版本6.9，海德堡工程公司）上进行成像。
结果
在2只眼中，OCTA显示无血管层存在新生血管复合体。该新生血管复合体的血管与来自浅表血管复合体的分支血管相连，这些分支血管穿过深层血管复合体到达无血管复合体。在第3只眼中，初次检查时OCTA未发现新生血管复合体，但在随后的检查中观察到荧光素渗漏，横断面OCTA进一步证实结节内存在血管造影血流。
结论
OCTA显示科茨病纤维化结节中存在3型新生血管形成。
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