Maxwell D B, Fisher E A, Ross-Clunis H A, Estep H L
J Am Coll Nutr. 1986;5(1):55-9. doi: 10.1080/07315724.1986.10720112.
Elevation of serum alkaline phosphatase concentration in patients with diabetes mellitus has been observed for several years, but the source and reasons are unknown. We report our experience with 39 diabetics, 38% of whom had an unexplained elevation of serum alkaline phosphatase. Isoenzyme determinations revealed bone fraction as the predominant species. Mean fasting serum glucose was significantly higher in the group with elevated alkaline phosphatase, supporting an association between the severity of diabetes and diabetic bone disease.
糖尿病患者血清碱性磷酸酶浓度升高已被观察到数年，但来源及原因尚不清楚。我们报告了39例糖尿病患者的情况，其中38%的患者血清碱性磷酸酶出现不明原因升高。同工酶测定显示骨同工酶为主要类型。碱性磷酸酶升高组的空腹血清葡萄糖均值显著更高，这支持了糖尿病严重程度与糖尿病性骨病之间的关联。
