Broulik P D, Stĕpán J J, Soucek K, Pacovský V
Clin Chim Acta. 1984 Jul 16;140(2):151-5. doi: 10.1016/0009-8981(84)90339-5.
There are conflicting data on the effects of lithium on bone metabolism. Bone formation is known to be reflected by the activity of alkaline phosphatase of the bone tissue. We have found significant differences in mean serum alkaline phosphatase and its bone isoenzyme levels between a group receiving lithium and a control group. In this study increased bone isoenzyme of alkaline phosphatase activity above the normal range was found in 27 of 41 patients treated with lithium carbonate. In 19 of 41 patients treated with lithium the activity of bone isoenzyme was increased above the normal range even in the absence of increased activity of serum total alkaline phosphatase.
关于锂对骨代谢的影响，存在相互矛盾的数据。已知骨组织碱性磷酸酶的活性可反映骨形成情况。我们发现接受锂治疗的组与对照组之间，血清碱性磷酸酶及其骨同工酶的平均水平存在显著差异。在本研究中，41例接受碳酸锂治疗的患者中有27例其骨碱性磷酸酶同工酶活性升高至正常范围以上。在41例接受锂治疗的患者中，有19例即使血清总碱性磷酸酶活性未升高，其骨同工酶活性也升高至正常范围以上。
