Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, SD, China.
Front Endocrinol (Lausanne). 2023 Mar 17;14:1153793. doi: 10.3389/fendo.2023.1153793. eCollection 2023.
Tissue-resident stem cells (TRSCs) have the ability to self-renew and differentiate throughout an individual's lifespan, and they utilize both mechanisms to maintain homeostasis and regenerate damaged tissues. Several studies suggest that these stem cells can serve as a potential source for cell-replacement-based therapy by promoting differentiation or expansion. In recent years, low-intensity pulsed ultrasound (LIPUS) has been demonstrated to effectively stimulate stem cell proliferation and differentiation, promote tissue regeneration, and inhibit inflammatory responses.
To present a comprehensive overview of current application and mechanism of LIPUS on tissue resident stem cells.
We searched PubMed, Web of Science for articles on the effects of LIPUS on tissue resident stem cells and its application.
The LIPUS could modulate cellular activities such as cell viability, proliferation and differentiation of tissue resident stem cells and related cells through various cellular signaling pathways. Currently, LIPUS, as the main therapeutic ultrasound, is being widely used in the treatment of preclinical and clinical diseases.
The stem cell research is the hot topic in the biological science, while in recent years, increasing evidence has shown that TRSCs are good targets for LIPUS-regulated regenerative medicine. LIPUS may be a novel and valuable therapeutic approach for the treatment of ophthalmic diseases. How to further improve its efficiency and accuracy, as well as the biological mechanism therein, will be the focus of future research.
组织驻留干细胞 (TRSCs) 具有在个体的整个生命周期中自我更新和分化的能力，它们利用这两种机制来维持体内平衡和再生受损组织。多项研究表明，这些干细胞可以通过促进分化或扩增来作为细胞替代治疗的潜在来源。近年来，低强度脉冲超声 (LIPUS) 已被证明可以有效刺激干细胞增殖和分化，促进组织再生，并抑制炎症反应。
全面介绍 LIPUS 对组织驻留干细胞的应用和作用机制。
我们在 PubMed、Web of Science 上搜索了关于 LIPUS 对组织驻留干细胞及其应用影响的文章。
LIPUS 可以通过多种细胞信号通路调节细胞活性，如细胞活力、组织驻留干细胞和相关细胞的增殖和分化。目前，LIPUS 作为主要的治疗超声，正在广泛应用于临床前和临床疾病的治疗。
干细胞研究是生物科学的热门话题，近年来，越来越多的证据表明 TRSCs 是 LIPUS 调节再生医学的良好靶点。LIPUS 可能是治疗眼部疾病的一种新的、有价值的治疗方法。如何进一步提高其效率和准确性，以及其中的生物学机制，将是未来研究的重点。
