Alkhorayef Nada, Almutery Fatimah T, Rasheed Zafar, Althwab Sami A, Aljohani Abdullah S M, Alhawday Yasser A N, Salem Tarek, Alharbi Abdulaziz M, Wahaq Abdulrahman A A B, Alharbi Fawaz S, Alghanem Abdulrhman S, Al Abdulmonem Waleed
Laboratory Department, College of Applied Medical Sciences, Al-Quway'iyah, Shaqra University, Riyadh, KSA.
General Directorate of Health Affairs, Qassim Region, Public Health Department, KSA.
J Taibah Univ Med Sci. 2023 Mar 21;18(5):1101-1107. doi: 10.1016/j.jtumed.2023.03.006. eCollection 2023 Oct.
In recent years, the use of a ketogenic diet (KD) against obesity has gained popularity in KSA. This study was designed to determine the impact of KD on anthropometric indices and on the abnormal regulation of inflammatory activities in obese Saudi women. Moreover, we investigated the potential of beta-hydroxybutyrate (BHB) supplementation on the inhibition of pro-inflammatory activities.
We enrolled 31 Saudi women (aged, 35.3 ± 8.4 years) with an average BMI of 33.96 ± 4.44 kg/m underwent an 8-week KD (8KD) from January to March 2021. Changes in anthropometric measurements were collected at baseline and after 4-8 weeks of intervention. Compliance with the dietary regimen was monitored weekly by plasma BHB level.
Twenty-nine females commenced the diets and 23 completed the study (a 79% completion rate). In comparison to pre-intervention, the 8KD resulted in a significant increase in the levels of plasma BHB (P < 0.001) throughout the duration of the trial. This was accompanied by a significant reduction in weight loss (7.7 kg ± 11.3; P < 0.001), BMI, waist circumference (P < 0.001), and levels of the inflammatory cytokine IL-1β (P < 0.001).
An 8-week KD was found to be useful in producing a positive impact on anthropometric indices, biochemical and inflammatory processes. This study indicated that the intake of a KD by obese Saudi women induced the release of BHB in the blood without stimulation of an overall starvation response. This may be useful to alleviate the severity of chronic inflammatory disorders associated with obesity.
近年来，生酮饮食（KD）用于对抗肥胖在沙特阿拉伯王国颇受青睐。本研究旨在确定KD对沙特肥胖女性人体测量指标及炎症活动异常调节的影响。此外，我们还研究了补充β-羟基丁酸（BHB）对抑制促炎活动的潜力。
我们招募了31名沙特女性（年龄35.3±8.4岁），她们的平均体重指数为33.96±4.44kg/m²，于2021年1月至3月接受了为期8周的生酮饮食（8KD）。在基线时以及干预4 - 8周后收集人体测量数据的变化。每周通过血浆BHB水平监测饮食方案的依从性。
29名女性开始饮食，23名完成研究（完成率79%）。与干预前相比，在整个试验期间，8KD导致血浆BHB水平显著升高（P<0.001）。同时伴有体重显著减轻（7.7kg±11.3；P<0.001）、BMI、腰围（P<0.001）以及炎症细胞因子IL-1β水平显著降低（P<0.001）。
发现为期8周的KD对人体测量指标、生化和炎症过程产生了积极影响。本研究表明，肥胖的沙特女性摄入KD可诱导血液中BHB的释放，而不会引发整体饥饿反应。这可能有助于减轻与肥胖相关的慢性炎症性疾病的严重程度。
