Department of Pharmacy, Jashore University of Science and Technology, Jashore, Bangladesh.
School of Pharmacy, BRAC University, Dhaka, Bangladesh.
Am J Alzheimers Dis Other Demen. 2023 Jan-Dec;38:15333175231214974. doi: 10.1177/15333175231214974.
Recently, some researchers claimed neuropathological changes lead to Alzheimer's-like brains after severe infection of SARS-CoV-2. Several mechanisms have been postulated on how SARS-CoV-2 neurological damage leads to Alzheimer's disease (AD) development. Neurobiochemical changes during infection may significantly induce Alzheimer's disease in severely COVID-19 infected people. The immune system is also compromised while infected by this novel coronavirus. However, recent studies are insufficient to conclude the relationship between Alzheimer's disease and COVID-19. This review demonstrates the possible pathways of neuropathological changes induced by the SARS-CoV-2 virus in AD patients or leading to AD in COVID-19 patients. Therefore, this study delineates the challenges for COVID-19 infected AD patients and the mechanism of actions of natural compounds and alternative treatments to overcome those. Furthermore, animal studies and a large cohort of COVID-19 survivors who showed neuroinflammation and neurological changes may augment the research to discover the relationship between Alzheimer's disease and COVID-19.
最近，一些研究人员声称，在严重感染 SARS-CoV-2 后，会导致类似于阿尔茨海默病的大脑发生神经病理学变化。已经提出了几种机制来解释 SARS-CoV-2 如何导致神经损伤进而引发阿尔茨海默病（AD）。感染过程中的神经生化变化可能会使严重 COVID-19 感染者显著患上阿尔茨海默病。感染这种新型冠状病毒时，免疫系统也会受到损害。然而，最近的研究还不足以得出阿尔茨海默病和 COVID-19 之间的关系的结论。本综述展示了 SARS-CoV-2 病毒在 AD 患者中引起的神经病理学变化或导致 COVID-19 患者发生 AD 的可能途径。因此，本研究阐述了感染 COVID-19 的 AD 患者所面临的挑战，以及天然化合物和替代疗法的作用机制，以克服这些挑战。此外，动物研究和大量表现出神经炎症和神经变化的 COVID-19 幸存者可能会进一步开展研究，以发现阿尔茨海默病和 COVID-19 之间的关系。
