Ejsmont Aleksander, Warowicka Alicja, Broniarczyk Justyna, Goscianska Joanna
Adam Mickiewicz University, Faculty of Chemistry, Department of Chemical Technology, Uniwersytetu Poznańskiego 8, Poznań 61-614, Poland.
Adam Mickiewicz University, Faculty of Biology, Department of Molecular Virology, Institute of Experimental Biology, Uniwersytetu Poznańskiego 6, Poznań 61-614, Poland.
Chem Commun (Camb). 2023 Apr 20;59(33):4907-4910. doi: 10.1039/d3cc00894k.
In this work, HKUST-1 and Cu-BDC nanoparticles were used as delivery systems for the early anti-COVID-19 drug, hydroxychloroquine. The antiviral MOF/drug combinations significantly reduced the infectivity of SARS-CoV-2, which can be attributed to the nanometric size of the carriers, the presence of copper in the MOF nodes, and the semi-controlled release of the drug.
在这项工作中，HKUST-1和Cu-BDC纳米颗粒被用作早期抗新冠病毒药物羟氯喹的递送系统。抗病毒的金属有机框架/药物组合显著降低了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的感染性，这可归因于载体的纳米尺寸、金属有机框架节点中铜的存在以及药物的半控释。
