Department of Bio-Convergence Engineering, Korea University, Seoul, 02841, Republic of Korea.
Interdisciplinary Program in Precision Public Health, Korea University, Seoul, 02841, Republic of Korea.
Small. 2023 Jul;19(27):e2300564. doi: 10.1002/smll.202300564. Epub 2023 Apr 3.
Having a permanent omniphobicity on the inner surface of the tube can bring enormous advantages, such as reducing resistance and avoiding precipitation during mass transfer. For example, such a tube can prevent blood clotting when delivering blood composed of complex hydrophilic and lipophilic compounds. However, it is very challenging to fabricate micro and nanostructures inside a tube. To overcome these, a wearability and deformation-free structural omniphobic surface is fabricated. The omniphobic surface can repel liquids by its "air-spring" under the structure, regardless of surface tension. Furthermore, it is not lost an omniphobicity under physical deformation like curved or twisted. By using these properties, omniphobic structures on the inner wall of the tube by the "roll-up" method are fabricated. Fabricated omniphobic tubes still repels liquids, even complex liquids like blood. According to the ex vivo blood tests for medical usage, the tube can reduce thrombus formation by 99%, like the heparin-coated tube. So, the surface will soon replace typical coating-based medical surfaces or anticoagulation blood vessels.
在管内表面上具有永久的全憎性有很多好处，例如可以减少阻力并避免传质过程中的沉淀。例如，当输送由复杂的亲水性和疏水性化合物组成的血液时，这样的管可以防止血液凝结。然而，在管内制造微纳结构非常具有挑战性。为了克服这些困难，制造了一种具有柔韧性和变形自由的结构全憎表面。该全憎表面可以通过结构下的“空气弹簧”排斥液体，而与表面张力无关。此外，它在像弯曲或扭曲这样的物理变形下不会失去全憎性。通过利用这些特性，通过“卷起”方法在管的内壁上制造全憎结构。制造的全憎管仍然排斥液体，即使是像血液这样的复杂液体。根据用于医疗用途的离体血液测试，该管可以将血栓形成减少 99%，就像肝素涂层管一样。因此，该表面将很快取代典型的基于涂层的医疗表面或抗凝血管。
