School of Pharmaceutical Science, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, China.
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Taiping road, Beijing, 100850, China.
Biomater Sci. 2023 May 16;11(10):3616-3628. doi: 10.1039/d3bm00075c.
The immediate control of a hemorrhage is crucial for reducing fatalities in critical situations such as battlefields, traffic accidents, natural disasters, . Most existing commercial hemostatic powders have weak adhesion capability and poor biodegradability, restricting their clinical use. In this paper, a new poly(ethylene glycol)-di(cyanoacrylate) (CA-PEG-CA)-based hemostatic powder with tissue-contact-triggered strong adhesion and controlled fast degradation is proposed. The monomers quickly underwent crosslinking polymerization while in contact with tissue or blood, forming an gel on the wound. The hemostatic mechanism was demonstrated to depend on both adhesive-based sealing and the aggregation of platelets and erythrocytes. The powder showed excellent hemostatic effects both and , even in a rat model with a weakened native hemostatic capacity. In addition, the poly-CA-PEG-CA gel could be rapidly biodegraded by ester bond hydrolysis. Notably, a cysteamine (CS)-containing solution could accelerate the degradation rate, endowing the gel with an on-demand removal property. This hemostatic powder not only can be used to efficiently control bleeding in emergency scenarios, but it can also allow nontraumatic re-exposure of wounds during subsequent surgical care. These properties make the CA-PEG-CA powder a promising candidate to act as a multifunctional wound care agent for first aid.
在战场、交通事故、自然灾害等危急情况下，迅速控制出血对于降低死亡率至关重要。大多数现有的商用止血粉的粘附能力较弱，生物降解性差，限制了它们的临床应用。本文提出了一种新型的聚乙二醇-二（氰基丙烯酸酯）（CA-PEG-CA）基止血粉，它具有组织接触触发的强粘附性和可控的快速降解性。单体在与组织或血液接触时迅速发生交联聚合，在伤口上形成凝胶。止血机制被证明依赖于基于粘附的密封和血小板和红细胞的聚集。该粉末在体内和体外均表现出优异的止血效果，即使在天然止血能力减弱的大鼠模型中也是如此。此外，聚 CA-PEG-CA 凝胶可以通过酯键水解快速生物降解。值得注意的是，含有半胱胺（CS）的溶液可以加速降解速率，使凝胶具有按需去除的特性。这种止血粉不仅可以有效地控制紧急情况下的出血，而且可以在随后的手术护理中实现非创伤性地重新暴露伤口。这些特性使 CA-PEG-CA 粉末成为一种有前途的多功能伤口护理剂，可用于急救。
