Zhao Yuzhou, Gao Yanni, Shen Zihao, Ni Mingze, Xu Juan, Wang Ting
Aulin College, Northeast Forestry University, Harbin 150000, China.
College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 26 Hexing Road, Harbin 150040, China.
Polymers (Basel). 2024 Jun 25;16(13):1795. doi: 10.3390/polym16131795.
A novel self-gelatinizing powder was designed to accelerate wound healing through enhanced hemostasis and tissue recovery. Significantly, this research addresses the critical need for innovative wound management solutions by presenting a novel approach. Carboxymethylcellulose calcium (CMC-Ca) was synthesized using an ion exchange method, and lysine (Lys) was integrated through physical mixing to augment the material's functional characteristics. The prepared powder underwent comprehensive evaluation for its self-gelling capacity, gelation time, adhesion, swelling rate, coagulation efficiency, hemostatic effectiveness, and wound healing promotion. Results indicate that the self-gelatinizing powder exhibited remarkable water absorption capabilities, absorbing liquid up to 30 times its weight and achieving rapid coagulation within 3 min. The inclusion of Lys notably enhanced the powder's gel-forming properties. The gelation time was determined to be within 4 s using a rotational rheometer, with the powder rapidly forming a stable gel on the skin surface. Furthermore, in a mouse skin injury model, near-complete skin recovery was observed within 14 days, underscoring the powder's impressive self-healing attributes and promising application prospects in wound management.
一种新型自凝胶化粉末被设计用于通过增强止血和组织恢复来加速伤口愈合。重要的是，本研究通过提出一种新方法，满足了对创新伤口管理解决方案的迫切需求。采用离子交换法合成了羧甲基纤维素钙（CMC-Ca），并通过物理混合加入赖氨酸（Lys）以增强材料的功能特性。对制备的粉末进行了自凝胶化能力、凝胶化时间、粘附性、膨胀率、凝血效率、止血效果和促进伤口愈合等方面的综合评估。结果表明，自凝胶化粉末具有显著的吸水能力，能吸收高达其重量30倍的液体，并在3分钟内实现快速凝血。赖氨酸的加入显著增强了粉末的凝胶形成性能。使用旋转流变仪测定凝胶化时间在4秒以内，该粉末能在皮肤表面迅速形成稳定的凝胶。此外，在小鼠皮肤损伤模型中，14天内观察到近乎完全的皮肤恢复，突出了该粉末令人印象深刻的自我愈合特性以及在伤口管理中广阔的应用前景。
