Zhu Wenping, Chen Yinlong, Liu Zengchen, Yang Weijie, Li Yanxia, Chen Yahong, Li Qingfeng, Cui Yali, Wang Baodui
College of Chemistry and Chemical Eningeering, Henan Key Laboratory of Rare Earth Functional Materials, International Joint Research Laboratory for Biomedical Nanomaterials of Henan; Zhoukou Key Laboratory of Nanosensing and Detection, Zhoukou Normal University, Zhoukou, 466001, P.R. China.
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu, 730000, P. R. China.
J Fluoresc. 2023 Nov;33(6):2241-2252. doi: 10.1007/s10895-023-03222-2. Epub 2023 Apr 3.
Cyclodextrin (CD) is an important guest material owing to the water solubility and biocompatibility. In the paper, an organic small molecule was synthesized. According to supramolecular self-assembly, the organic molecule was bounded to the cavity of Poly β-cyclodextrin, which was characterized by IR, SEM and TEM et al. After self-assembly interaction, the morphology has changed obviously comparing with precursors. Simultaneously, the supramolecular self-assembly complex exhibited good water solubility. Moreover, By Gaussian calculation, the high binding activity between organic molecule and cyclodextrin was confirmed. By fluorescence investigation, the supramolecular system showed high fluorescence sensing activity for Zn in pure water environment, which could track the dynamic change of Zn in organisms. In addition, the supramolecular system exhibited low cytotoxicity. The work provided an interesting pathway for constructing water-soluble and low cytotoxic fluorescence sensor for Zn.
环糊精（CD）因其水溶性和生物相容性而成为一种重要的客体材料。本文合成了一种有机小分子。根据超分子自组装原理，该有机分子与聚β-环糊精的空腔结合，通过红外光谱（IR）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）等手段对其进行了表征。自组装相互作用后，其形态与前体相比有明显变化。同时，超分子自组装复合物表现出良好的水溶性。此外，通过高斯计算，证实了有机分子与环糊精之间具有较高的结合活性。通过荧光研究发现，该超分子体系在纯水环境中对锌具有高荧光传感活性，能够追踪生物体中锌的动态变化。此外，该超分子体系表现出低细胞毒性。这项工作为构建水溶性且低细胞毒性的锌荧光传感器提供了一条有趣的途径。
