定植微生物群落在生物膜相关植入物感染中的作用：最新研究进展与启示。
Role of Resident Microbial Communities in Biofilm-Related Implant Infections: Recent Insights and Implications.
机构信息
Department of Anesthesia, Acute Care Surgery, and Surgical Critical Care, Department of Surgery, Duke University Medical Center, Duke University School of Medicine, Durham, North Carolina, USA.
Division of Trauma, Acute Care Surgery, and Surgical Critical Care, Department of Surgery, Duke University Medical Center, Duke University School of Medicine, Durham, North Carolina, USA.
出版信息
Surg Infect (Larchmt). 2023 Apr;24(3):258-264. doi: 10.1089/sur.2023.009.
The use of medical implants continues to grow as the population ages. Biofilm-related implant infection is the leading cause of medical implant failure and remains difficult to diagnose and treat. Recent technologies have enhanced our understanding of the composition and complex functions of microbiota occupying various body site niches. In this review, we leverage data from molecular sequencing technologies to explore how silent changes in microbial communities from various sites can influence the development of biofilm-related infections. Specifically, we address biofilm formation and recent insights of the organisms involved in biofilm-related implant infections; how composition of microbiomes from skin, nasopharyngeal, and nearby tissue can impact biofilm-formation, and infection; the role of the gut microbiome in implant-related biofilm formation; and therapeutic strategies to mitigate implant colonization.
随着人口老龄化，医用植入物的使用不断增加。与生物膜相关的植入物感染是导致医用植入物失效的主要原因，且仍然难以诊断和治疗。最近的技术提高了我们对占据各种身体部位生态位的微生物群落的组成和复杂功能的理解。在这篇综述中，我们利用来自分子测序技术的数据来探讨来自不同部位的微生物群落的沉默变化如何影响生物膜相关感染的发展。具体而言，我们讨论生物膜的形成以及与生物膜相关的植入物感染相关的生物体的最新见解；皮肤、鼻咽和附近组织的微生物组组成如何影响生物膜形成和感染；肠道微生物组在植入物相关生物膜形成中的作用；以及减轻植入物定植的治疗策略。
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