Coenye Tom, Spittaels Karl-Jan, Achermann Yvonne
Laboratory of Pharmaceutical Microbiology, Ghent University, Gent, Belgium.
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Biofilm. 2021 Dec 9;4:100063. doi: 10.1016/j.bioflm.2021.100063. eCollection 2022 Dec.
(previously known as ) is frequently found on lipid-rich parts of the human skin. While is most known for its role in the development and progression of the skin disease acne, it is also involved in many other types of infections, often involving implanted medical devices. readily forms biofilms and there is growing evidence that biofilm formation by this Gram-positive, facultative anaerobic micro-organism plays an important role and is also involved in treatment failure. In this brief review we present an overview on what is known about biofilms (including their role in pathogenesis and reduced susceptibility to antibiotics), discuss model systems that can be used to study these biofilms and and give an overview of interspecies interactions occurring in polymicrobial communities containing .
(以前称为 )经常在人体皮肤富含脂质的部位被发现。虽然 最出名的是其在皮肤病痤疮的发生和发展中所起的作用,但它也涉及许多其他类型的感染,常常涉及植入式医疗设备。 很容易形成生物膜,并且越来越多的证据表明,这种革兰氏阳性兼性厌氧微生物形成生物膜起着重要作用,并且还与治疗失败有关。在这篇简短的综述中,我们概述了关于 生物膜的已知情况(包括它们在发病机制中的作用以及对抗生素敏感性降低),讨论了可用于研究这些生物膜的模型系统,并且概述了在含有 的多微生物群落中发生的种间相互作用。