Yoshino K, Shibukawa T, Takahashi K, Kitao M
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Mar;38(3):423-6.
We studied changes in catecholamines, as related to estrogen positive feedback mechanisms, and we measured two catecholamine metabolites (DOPAC, MHPG) in the plasma, using high performance liquid chromatography. In the case of the mean MHPG level, the mean values for two groups in which LH levels were from 100 to 200 percent of the basal level of LH and under the basal level of LH were significantly higher than that of a group in which the LH level was double the value for the basal level of LH. But the mean basal DOPAC level showed no significant difference among the three groups. In the good LH reaction group, the MHPG level at 24 and 48 hours after estrogen injection was significantly higher than the mean basal MHPG level. But in other two groups, the mean MHPG levels showed no significant differences. In the case of DOPAC, there was no significant difference in any group. All these observations taken together suggested that in vivo, catecholamines may influence the secretion of gonadotropins.
我们研究了与雌激素正反馈机制相关的儿茶酚胺变化，并使用高效液相色谱法测量了血浆中的两种儿茶酚胺代谢物（二羟基苯乙酸、3-甲氧基-4-羟基苯乙二醇）。就平均3-甲氧基-4-羟基苯乙二醇水平而言，促黄体生成素（LH）水平为基础水平的100%至200%以及低于基础水平的两组的平均值显著高于促黄体生成素水平为基础水平两倍的组。但平均基础二羟基苯乙酸水平在三组之间无显著差异。在促黄体生成素反应良好的组中，雌激素注射后24小时和48小时的3-甲氧基-4-羟基苯乙二醇水平显著高于平均基础3-甲氧基-4-羟基苯乙二醇水平。但在其他两组中，平均3-甲氧基-4-羟基苯乙二醇水平无显著差异。就二羟基苯乙酸而言，任何组均无显著差异。综合所有这些观察结果表明，在体内，儿茶酚胺可能影响促性腺激素的分泌。
