Department of Health Management Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Henan Reproductive Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Biochim Biophys Acta Rev Cancer. 2023 May;1878(3):188894. doi: 10.1016/j.bbcan.2023.188894. Epub 2023 Apr 1.
Cervical cancer (CC) is an important public health problem for women, and perspectives and information regarding its prevention and treatment are quickly evolving. Human papilloma virus (HPV) has been recognized as a major contributor to CC development; however, HPV infection is not the only cause of CC. Epigenetics refers to changes in gene expression levels caused by non-gene sequence changes. Growing evidence suggests that the disruption of gene expression patterns which were governed by epigenetic modifications can result in cancer, autoimmune diseases, and various other maladies. This article mainly reviews the current research status of epigenetic modifications in CC based on four aspects, respectively DNA methylation, histone modification, noncoding RNA regulation and chromatin regulation, and we also discuss their functions and molecular mechanisms in the occurrence and progression of CC. This review provides new ideas for early screening, risk assessment, molecular targeted therapy and prognostic prediction of CC.
宫颈癌（CC）是女性面临的一个重要公共卫生问题，有关其预防和治疗的观点和信息正在迅速发展。人乳头瘤病毒（HPV）已被认为是 CC 发展的主要因素；然而，HPV 感染并不是 CC 的唯一原因。表观遗传学是指由非基因序列变化引起的基因表达水平变化。越来越多的证据表明，由表观遗传修饰控制的基因表达模式的破坏可能导致癌症、自身免疫性疾病和各种其他疾病。本文主要从 DNA 甲基化、组蛋白修饰、非编码 RNA 调控和染色质调控四个方面综述了 CC 中表观遗传修饰的研究现状，并讨论了它们在 CC 发生和发展中的功能和分子机制。本综述为 CC 的早期筛查、风险评估、分子靶向治疗和预后预测提供了新思路。
