Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.
Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Centre, Leiden, Netherlands.
Nat Commun. 2023 Apr 3;14(1):1863. doi: 10.1038/s41467-023-37502-z.
Schistosomiasis is a parasitic disease affecting over 200 million people in multiple organs, including the lungs. Despite this, there is little understanding of pulmonary immune responses during schistosomiasis. Here, we show type-2 dominated lung immune responses in both patent (egg producing) and pre-patent (larval lung migration) murine Schistosoma mansoni (S. mansoni) infection. Human pre-patent S. mansoni infection pulmonary (sputum) samples revealed a mixed type-1/type-2 inflammatory cytokine profile, whilst a case-control study showed no significant pulmonary cytokine changes in endemic patent infection. However, schistosomiasis induced expansion of pulmonary type-2 conventional dendritic cells (cDC2s) in human and murine hosts, at both infection stages. Further, cDC2s were required for type-2 pulmonary inflammation in murine pre-patent or patent infection. These data elevate our fundamental understanding of pulmonary immune responses during schistosomiasis, which may be important for future vaccine design, as well as for understanding links between schistosomiasis and other lung diseases.
血吸虫病是一种寄生虫病，影响全球 2 亿多人的多个器官，包括肺部。尽管如此，人们对血吸虫病期间的肺部免疫反应知之甚少。在这里，我们在有症状（产卵）和无症状（幼虫肺部迁移）的曼氏血吸虫（S. mansoni）感染的小鼠中均显示出 2 型主导的肺部免疫反应。人类无症状的曼氏血吸虫感染的肺部（痰）样本显示出混合的 1/2 型炎症细胞因子谱，而病例对照研究表明在地方性有症状感染中没有明显的肺部细胞因子变化。然而，血吸虫病在人类和小鼠宿主中诱导了肺部 2 型常规树突状细胞（cDC2）的扩张，在感染的两个阶段均如此。此外，cDC2 在小鼠无症状或有症状感染中的 2 型肺部炎症中是必需的。这些数据提高了我们对血吸虫病期间肺部免疫反应的基本认识，这对于未来的疫苗设计以及理解血吸虫病与其他肺部疾病之间的联系可能很重要。
