AlDarrab A, Al Jarallah O J, Al Balawi H B
Department of Surgery, College of Medicine, Prince Sattam Bin Abdulaziz University, AlKharj, Saudi Arabia.
Eur Rev Med Pharmacol Sci. 2023 Mar;27(6):2419-2427. doi: 10.26355/eurrev_202303_31776.
We designed this systematic review to summarize the diabetes-related glaucoma articles produced from 2011 to 2022. We further aimed to perform a meta-analysis to determine the vital association between these two parameters.
Data sources like PubMed, MEDLINE, and EMBASE were used to find the relevant research. Reviews, case reports, and editorial letters were excluded. Articles inspection was conducted by the main author who extracted the study title and abstract in the first screening by using keywords to find the eligible articles. Heterogeneity was accessed by using the Cochrane Q test and I2 test.
10 studies were reported with 2,702,136 cases of diabetes. Out of these, 64,998 incidents of glaucoma were observed. The pooled prevalence of diabetic retinopathy was 11.7% associated with glaucoma. A significant I2 value was achieved (100%) with Cochran's Q of 183.6.
In conclusion, we found diabetes duration, elevated IOP, and fasting glucose levels are one of the leading risk factors for glaucoma. Fasting glucose levels and diabetes are also major contributors to elevated IOP levels.
我们开展这项系统评价以总结2011年至2022年发表的与糖尿病相关的青光眼文章。我们进一步旨在进行荟萃分析，以确定这两个参数之间的重要关联。
使用PubMed、MEDLINE和EMBASE等数据源查找相关研究。排除综述、病例报告和编辑信件。由第一作者进行文章筛选，其在首次筛选时通过使用关键词提取研究标题和摘要来找出符合条件的文章。使用Cochrane Q检验和I²检验评估异质性。
报告了10项研究，涉及2702136例糖尿病患者。其中，观察到64998例青光眼发病病例。糖尿病视网膜病变合并青光眼的汇总患病率为11.7%。Cochran's Q值为183.6，I²值达到显著水平（100%）。
总之，我们发现糖尿病病程、眼压升高和空腹血糖水平是青光眼的主要危险因素之一。空腹血糖水平和糖尿病也是眼压升高的主要因素。
