State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China.
Protein Cell. 2023 Oct 25;14(10):776-785. doi: 10.1093/procel/pwad016.
Interactions between gut microbiome and host immune system are fundamental to maintaining the intestinal mucosal barrier and homeostasis. At the host-gut microbiome interface, cell wall-derived molecules from gut commensal bacteria have been reported to play a pivotal role in training and remodeling host immune responses. In this article, we review gut bacterial cell wall-derived molecules with characterized chemical structures, including peptidoglycan and lipid-related molecules that impact host health and disease processes via regulating innate and adaptive immunity. Also, we aim to discuss the structures, immune responses, and underlying mechanisms of these immunogenic molecules. Based on current advances, we propose cell wall-derived components as important sources of medicinal agents for the treatment of infection and immune diseases.
肠道微生物组与宿主免疫系统的相互作用对于维持肠道黏膜屏障和体内平衡至关重要。在宿主-肠道微生物组界面上，来自肠道共生菌的细胞壁衍生分子已被报道在训练和重塑宿主免疫反应方面发挥关键作用。在本文中，我们综述了具有明确化学结构的肠道细菌细胞壁衍生分子，包括肽聚糖和脂质相关分子，它们通过调节先天和适应性免疫来影响宿主的健康和疾病过程。此外，我们还旨在讨论这些免疫原性分子的结构、免疫反应和潜在机制。基于当前的进展，我们提出细胞壁衍生成分是治疗感染和免疫性疾病的药物的重要来源。
