Sorabad Ganesh Shivayogappa, Yang Ding-Yah
Department of Chemistry, Tunghai University, Taichung 407224, Taiwan.
Graduate Program for Biomedical and Materials Science, Tunghai University No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung 407224, Taiwan.
Org Lett. 2023 Apr 14;25(14):2515-2519. doi: 10.1021/acs.orglett.3c00683. Epub 2023 Apr 4.
A base-mediated [4 + 3] cycloaddition reaction of sulfonylphthalide with ,-cyclic azomethine imines to facilely synthesize novel pyrimidinone-fused naphthoquinones is described. The prepared compounds can be readily converted to isoquinoline-1,4-dione derivatives via alkaline methanolysis. Alternatively, the isoquinoline-1,4-dione can also be prepared by base-mediated one-pot three-component reaction of sulfonylphthalide with ,-cyclic azomethine imines in methanol.
描述了一种碱介导的磺酰基邻苯二甲酰亚胺与α,β-环状甲亚胺亚胺的[4 + 3]环加成反应，用于简便地合成新型嘧啶酮稠合萘醌。所制备的化合物可通过碱性甲醇解轻松转化为异喹啉-1,4-二酮衍生物。另外，异喹啉-1,4-二酮也可通过磺酰基邻苯二甲酰亚胺与α,β-环状甲亚胺亚胺在甲醇中的碱介导一锅三组分反应制备。
