Ohno Haruki, Takahashi Ryosuke, Suga Takuya, Soeta Takahiro, Ukaji Yutaka
Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan.
Org Biomol Chem. 2023 Oct 11;21(39):7891-7894. doi: 10.1039/d3ob01165h.
,-cyclic-'-acyl azomethine imines with isoquinoline skeletons were investigated for their reactivity with diazo compounds two different pathways. During the reaction with ethyl diazoacetate, an α-diazoacetate moiety was introduced at the C1-position of the resulting tetrahydroisoquinolines. Alternatively, diazomethane or trimethylsilyldiazomethane was used to synthesize 3-benzazepine derivatives ring expansion.
研究了具有异喹啉骨架的 - 环 - '- 酰基偶氮甲碱亚胺与重氮化合物的两种不同反应途径。在与重氮乙酸乙酯反应过程中，在所得四氢异喹啉的C1位引入了α - 重氮乙酸酯部分。或者，使用重氮甲烷或三甲基硅基重氮甲烷通过环扩展合成3 - 苯并氮杂卓衍生物。
