Emory University School of Medicine , Atlanta, GA, USA.
J Gen Physiol. 2023 May 1;155(5). doi: 10.1085/jgp.202313343. Epub 2023 Apr 4.
CFTR, unique among ABC transporters, evolved to function as an ion channel in part by optimizing the stability of the open state.
CFTR 在 ABC 转运蛋白中独一无二,其作为离子通道的功能部分是通过优化开放状态的稳定性来实现的。