Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana, Samsthana (S-VYASA), #19 Eknath Bhavan, Gavipuram Circle, K.G. Nagar, Bangalore, 560019, India.
Acta Diabetol. 2023 Jul;60(7):951-961. doi: 10.1007/s00592-023-02085-0. Epub 2023 Apr 4.
Type 2 diabetes mellitus (T2DM) alters brain functional and structural connectivity leading to cognitive dysfunction. This study examined the effect of a 12-week yoga intervention on prefrontal cortex (PFC) oxygenation and working memory in patients with T2DM.
Fifty participants were randomized into yoga and waitlist control groups. The yoga protocol specific to T2DM was followed. The pre- (day 1), mid- (6 weeks) and post-intervention (12 weeks) assessments included measurement of PFC oxygenation while performing working memory tasks (n-back) using functional near-infrared spectroscopy.
Following a 12-week intervention, the yoga group showed improved performance in working memory [accuracy (geometric mean difference of 3.15%, 95% CI [2.33,3.96], p = 0.001) and reaction time (mean difference of 100.8 milliseconds,95% CI [- 166.6, - 35.1], p = 0.002] in the high task load (2-back) associated with higher oxygenation in dorsolateral PFC (β coefficient mean difference of 95.6, 95% CI [0.23,191], p = 0.049) and ventrolateral PFC (β coefficient mean difference of 53.4, 95% CI [7.8,98.9], p = 0.018) regions. Higher oxygenation in dorsolateral PFC during 2-back task was positively correlated with accuracy (r(23) = 0.65, p < 0.001) and negatively correlated with reaction time (r(23) = - 0.47,p = 0.017).
Integrated yoga practice may improve working memory performance associated with higher PFC oxygenation in patients with T2DM. As 12 weeks of yoga intervention improved working memory performance, the regular practice of yoga may have the potential to prevent decline of cognitive functions in clinical conditions.
2 型糖尿病（T2DM）改变大脑的功能和结构连接，导致认知功能障碍。本研究旨在探讨 12 周瑜伽干预对 T2DM 患者前额叶皮层（PFC）氧合和工作记忆的影响。
50 名参与者被随机分为瑜伽组和候补对照组。遵循针对 T2DM 的特定瑜伽方案。在干预前（第 1 天）、干预中（6 周）和干预后（12 周）评估中，使用功能近红外光谱技术测量执行工作记忆任务（n 回）时 PFC 氧合。
经过 12 周的干预，瑜伽组在高任务负荷（2 回）的工作记忆表现（准确性[几何均数差异为 3.15%，95%置信区间[2.33,3.96]，p=0.001]和反应时间[平均差异为 100.8 毫秒，95%置信区间[-166.6,-35.1]，p=0.002]）上有所改善，与背外侧前额叶皮层（dorsolateral PFC）的氧合增加有关（β 系数平均差异为 95.6，95%置信区间[0.23,191]，p=0.049）和腹外侧前额叶皮层（ventrolateral PFC）（β 系数平均差异为 53.4，95%置信区间[7.8,98.9]，p=0.018）。2 回任务中背外侧 PFC 的氧合增加与准确性呈正相关（r（23）=0.65，p<0.001），与反应时间呈负相关（r（23）=-0.47，p=0.017）。
综合瑜伽练习可能会改善 T2DM 患者的工作记忆表现，与 PFC 氧合增加有关。由于 12 周的瑜伽干预改善了工作记忆表现，因此定期进行瑜伽练习可能有潜力预防认知功能在临床情况下下降。
