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CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells.CRTC1-MAML2 融合诱导长非编码 RNA LINC00473 的表达维持人黏液表皮样癌细胞的生长和存活。
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Sclerosing mucoepidermoid carcinoma of salivary glands.唾液腺硬化性黏液表皮样癌
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Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2- rearranged salivary gland tumours.黏液表皮样癌通过免疫组织化学检查可能缺乏鳞状细胞：扩展MAML2重排唾液腺肿瘤的组织学和免疫组织化学谱。
Histopathology. 2023 Jan;82(2):305-313. doi: 10.1111/his.14817. Epub 2022 Oct 28.
2
Diagnostic utility of p63/p40 in the histologic differentiation of salivary gland tumors: A systematic review.p63/p40 在唾液腺肿瘤组织学鉴别诊断中的应用价值：系统评价。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Feb;133(2):189-198. doi: 10.1016/j.oooo.2021.07.010. Epub 2021 Jul 21.
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Mucoepidermoid carcinoma of the salivary glands revisited with special reference to histologic grading and CRTC1/3-MAML2 genotyping.唾液腺黏液表皮样癌的再探讨，特别涉及组织学分级和 CRTC1/3-MAML2 基因分型。
Virchows Arch. 2021 Nov;479(5):975-985. doi: 10.1007/s00428-021-03146-x. Epub 2021 Jul 7.
4
Mucoacinar Carcinoma: A Rare Variant of Mucoepidermoid Carcinoma.黏液腺泡癌：黏液表皮样癌的一种罕见变异型。
Am J Surg Pathol. 2021 Aug 1;45(8):1028-1037. doi: 10.1097/PAS.0000000000001752.
5
Molecular Profiling of Salivary Oncocytic Mucoepidermoid Carcinomas Helps to Resolve Differential Diagnostic Dilemma With Low-grade Oncocytic Lesions.涎腺嗜酸性黏液表皮样癌的分子特征分析有助于解决与低级别嗜酸性病变的鉴别诊断难题。
Am J Surg Pathol. 2020 Dec;44(12):1612-1622. doi: 10.1097/PAS.0000000000001590.
6
High Grade Transformation in Mucoepidermoid Carcinoma of the Minor Salivary Gland with Polyploidy of the Rearranged MAML2 Gene.涎腺黏液表皮样癌中伴有 MAML2 基因重排的多倍体高级别转化。
Head Neck Pathol. 2020 Sep;14(3):822-827. doi: 10.1007/s12105-019-01064-8. Epub 2019 Sep 18.
7
Warthin-like Mucoepidermoid Carcinoma of the Parotid Gland: Unusual Morphology and Diagnostic Pitfalls.腮腺沃辛样黏液表皮样癌：不寻常的形态学及诊断陷阱
Anticancer Res. 2019 Jun;39(6):3213-3217. doi: 10.21873/anticanres.13461.
8
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A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance.汗腺腺瘤中一种新型融合基因 CRTC3-MAML2：组织病理学意义。
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The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.分子检测在唾液腺癌鉴别诊断中的作用。
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“单纯型”黏液表皮样癌的挑战——纯梭形-透明细胞形态罕见病例报告。

The Challenge of "Monomorphic" Mucoepidermoid Carcinoma-Report of a Rare Case with Pure Spindle-Clear Cell Morphology.

机构信息

Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, 119074, Singapore, Singapore.

Department of Pathology, Singapore General Hospital, Singapore, Singapore.

出版信息

Head Neck Pathol. 2023 Sep;17(3):864-870. doi: 10.1007/s12105-023-01547-9. Epub 2023 Apr 4.

DOI:10.1007/s12105-023-01547-9
PMID:37014573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10513994/
Abstract

BACKGROUND

Mucoepidermoid carcinoma is a malignant salivary gland tumor which, in most cases, is composed of variable proportions of mucous, epidermoid, and intermediate cells.

METHODS

We report a case of parapharyngeal mucoepidermoid carcinoma with highly unusual ("monomorphic") light microscopic features as well as atypical immunohistochemical properties. Molecular analysis was performed using the TruSight RNA fusion panel.

RESULTS

The tumor featured heretofore undescribed histopathological features: sheets and nests composed of monomorphic neoplastic (plump spindle to epithelioid) cells with no mucous, intermediate, glandular/columnar, or any other cell type identified. The neoplastic cells displayed variable clear cell change and only expressed cytokeratin 7. Despite this non-classical morphology, the presence of the classical CRTC1::MAML2 fusion was demonstrated.

CONCLUSIONS

Mucoepidermoid carcinoma featuring a uniform ("monomorphic") population of neoplastic cells is a novel observation. A confident diagnosis of mucoepidermoid carcinoma can be made upon detection of the CRTC1/3::MAML2 fusion. Our case increases the spectrum of histopathological appearances that mucoepidermoid carcinoma may display.

摘要

背景

黏液表皮样癌是一种恶性涎腺肿瘤，在大多数情况下，由不同比例的黏液、表皮样和中间细胞组成。

方法

我们报告了一例咽旁黏液表皮样癌，其具有非常罕见的（“同形性”）光镜特征以及非典型的免疫组织化学特征。使用 TruSight RNA 融合 panel 进行了分子分析。

结果

肿瘤具有前所未有的组织病理学特征：由同形性肿瘤细胞（肥胖的纺锤形至上皮样）组成的片状和巢状结构，没有黏液、中间、腺/柱状或任何其他细胞类型。肿瘤细胞显示出不同程度的透明细胞改变，仅表达细胞角蛋白 7。尽管存在这种非典型形态，但检测到了经典的 CRTC1::MAML2 融合。

结论

以均匀（“同形性”）的肿瘤细胞群为特征的黏液表皮样癌是一种新的观察结果。在检测到 CRTC1/3::MAML2 融合时，可以做出明确的黏液表皮样癌诊断。我们的病例增加了黏液表皮样癌可能表现出的组织病理学表现谱。