State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
ACS Biomater Sci Eng. 2023 May 8;9(5):2235-2250. doi: 10.1021/acsbiomaterials.2c01553. Epub 2023 Apr 4.
Serum albumin (SA), one of the most abundant proteins in blood plasma, plays essential roles in all living processes and has been used in various biomedical applications. Biomaterials fabricated from SAs (human SA, bovine SA, and ovalbumin) exhibit proper microstructure and hydrophilicity as well as remarkable biocompatibility; this makes them ideal for use in bone regeneration. This review provides a comprehensive overview of the structure, physicochemical properties, and biological features of SAs. SAs can be used to generate a wide array of biomaterials for bone repair because of their flexible structure and diverse functions, which enables us to control structure and morphology as well as modulate the biological responses with host tissue. This review summarizes the material categories, forms, and fabrication methods of SA in bone repair. Finally, concerns for future studies in biomedical fields with SA-derived biomaterials are discussed.
血清白蛋白（SA）是血浆中最丰富的蛋白质之一，在所有生命过程中都起着至关重要的作用，并已被应用于各种生物医学领域。由 SA（人 SA、牛 SA 和卵清蛋白）制成的生物材料具有适当的微观结构和亲水性以及显著的生物相容性；这使得它们成为骨再生的理想材料。本综述全面概述了 SA 的结构、物理化学性质和生物学特性。由于其灵活的结构和多种功能，SA 可用于生成广泛的用于骨修复的生物材料，使我们能够控制结构和形态，并调节与宿主组织的生物反应。本综述总结了 SA 在骨修复中的材料类别、形式和制造方法。最后，讨论了基于 SA 的生物材料在生物医学领域未来研究中的关注点。
