Shackelford P G, Polmar S H, Mayus J L, Johnson W L, Corry J M, Nahm M H
J Pediatr. 1986 May;108(5 Pt 1):647-53. doi: 10.1016/s0022-3476(86)81035-6.
Serum immunoglobulins and IgG subclasses were measured in 30 children with recurrent infections. Seven patients had low IgG2 concentrations (less than 3SD below the geometric mean for age). Four of these seven patients had normal concentrations of IgG, IgA and IgM, and thus would have been considered immunologically normal by routine criteria. The seven children with IgG2 deficiency had more severe infections than the 23 children with normal IgG2. Five children had recurrent pneumonia or sinusitis, one had recurrent invasive Haemophilus influenzae type b infections, and one had severe pneumococcal meningitis. Their immunologic abnormalities were heterogeneous. Two children had isolated IgG2 deficiency, two had IgG2-IgG4 deficiency, one had IgG2-IgG4-IgA deficiency, one had IgG2-IgA deficiency, and one had severe IgG1-IgG2 deficiency with abnormal T cell function and thrombocytopenia. Thus IgG2 deficiency occurs frequently among children with recurrent infections, and is associated with a variety of clinical and immunologic abnormalities.
对30例反复感染的儿童测定了血清免疫球蛋白和IgG亚类。7例患者IgG2浓度较低（低于年龄几何平均值3个标准差以下）。这7例患者中有4例IgG、IgA和IgM浓度正常，因此按常规标准会被认为免疫功能正常。7例IgG2缺乏的儿童比23例IgG2正常的儿童感染更严重。5例儿童反复发生肺炎或鼻窦炎，1例反复发生侵袭性b型流感嗜血杆菌感染，1例发生严重肺炎球菌脑膜炎。他们的免疫异常是异质性的。2例儿童为单纯IgG2缺乏，2例为IgG2-IgG4缺乏，1例为IgG2-IgG4-IgA缺乏，1例为IgG2-IgA缺乏，1例为严重的IgG1-IgG2缺乏伴T细胞功能异常和血小板减少。因此，IgG2缺乏在反复感染的儿童中很常见，并与多种临床和免疫异常有关。
