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Molecular basis for METTL9-mediated N1-histidine methylation.

作者信息

Wang Xiaoyang, Xie Huabin, Guo Qiong, Cao Dan, Ru Wenwen, Zhao Shidong, Zhu Zhongliang, Zhang Jiahai, Pan Wen, Yao Xuebiao, Xu Chao

机构信息

MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Institute of Immunology, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

出版信息

Cell Discov. 2023 Apr 4;9(1):38. doi: 10.1038/s41421-023-00548-w.

DOI:10.1038/s41421-023-00548-w
PMID:37015930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10073072/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ab/10073072/9d73ac403317/41421_2023_548_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ab/10073072/9d73ac403317/41421_2023_548_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ab/10073072/9d73ac403317/41421_2023_548_Fig1_HTML.jpg

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Highly accurate protein structure prediction with AlphaFold.利用 AlphaFold 进行高精度蛋白质结构预测。
Nature. 2021 Aug;596(7873):583-589. doi: 10.1038/s41586-021-03819-2. Epub 2021 Jul 15.
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Protein Cell. 2021 Dec;12(12):965-970. doi: 10.1007/s13238-021-00857-4. Epub 2021 Jul 4.
3
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NPJ Precis Oncol. 2025 Jun 16;9(1):186. doi: 10.1038/s41698-025-01004-6.
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Orthologues of the human protein histidine methyltransferase METTL9 display distinct substrate specificities.人类蛋白质组氨酸甲基转移酶METTL9的直系同源物表现出不同的底物特异性。
J Biol Chem. 2025 May 30;301(7):110318. doi: 10.1016/j.jbc.2025.110318.
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Structural and functional analysis of SAM-dependent N-methyltransferases involved in ovoselenol and ovothiol biosynthesis.参与卵硒醇和卵硫醇生物合成的依赖S-腺苷甲硫氨酸的N-甲基转移酶的结构与功能分析
Structure. 2025 Mar 6;33(3):528-538.e5. doi: 10.1016/j.str.2024.12.020. Epub 2025 Jan 24.
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Autoimmune disease: a view of epigenetics and therapeutic targeting.自身免疫性疾病：表观遗传学与治疗靶点的视角
Front Immunol. 2024 Nov 13;15:1482728. doi: 10.3389/fimmu.2024.1482728. eCollection 2024.
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