金属有机笼与DNA的单分子缀合物的构建。
Creation of single molecular conjugates of metal-organic cages and DNA.
作者信息
Nakajo Toshinobu, Kusaka Shinpei, Hiraoka Haruka, Nomura Kohei, Matsubara Noriaki, Baba Rintaro, Yoshida Yuki, Nakamoto Kosuke, Honma Masakazu, Iguchi Hiroaki, Uchihashi Takayuki, Abe Hiroshi, Matsuda Ryotaro
机构信息
Department of Chemistry and Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
Department of Chemistry, School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.
出版信息
Chem Commun (Camb). 2023 Apr 20;59(33):4974-4977. doi: 10.1039/d3cc00460k.
Here we report the development of an equimolar conjugate of a metal-organic cage (MOC) and DNA (MOC-DNA). Several MOC-DNA conjugates were assembled into a programmed structure by coordinating with a template DNA having a complementary base sequence. Moreover, conjugation with the MOC drastically enhanced the permeability of DNA through the lipid bilayer, presenting great potential as a drug delivery system.
在此，我们报告了一种金属有机笼（MOC）与DNA的等摩尔共轭物（MOC-DNA）的研发情况。通过与具有互补碱基序列的模板DNA配位，几种MOC-DNA共轭物被组装成一种程序化结构。此外，与MOC的共轭显著提高了DNA透过脂质双层的通透性，作为一种药物递送系统展现出巨大潜力。
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