School of Psychological and Cognitive Sciences, Peking University, Beijing, P. R. China.
Department of General Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P. R. China.
Brain Behav. 2023 May;13(5):e2952. doi: 10.1002/brb3.2952. Epub 2023 Apr 5.
This study aimed to investigate the effectiveness of phototherapy intervention on cognitive function in older adult patients with dementia. PubMed, Ovid MEDLINE, Web of Science, EMBASE, Cochrane Central Registry of Controlled Trials, PsycINFO, and Clinical Trials were searched from their inception to August 10, 2022, for randomized controlled trials involving patients with dementia who received phototherapy interventions. We used the weighted mean difference (MD) or standard weighted mean difference to generate the pooled estimates. The primary outcome was cognitive function as measured by the Mini-Mental State Examination (MMSE) score. The secondary outcomes were the behavioral and psychological symptoms of dementia (BPSDs) and sleep. This systematic review and meta-analysis was registered in PROSPERO (registration number: CRD42022343788). We included 12 randomized controlled trials comprising 766 patients with dementia (426 patients in the intervention group and 340 in the control group). Phototherapy interventions significantly improved MMSE scores (n = 3, MD 2.68, 95% confidence interval [CI]: 1.38-3.98, I = 0%). There were no significant differences in the Cornell Scale for Depression in Dementia score, Cohen-Mansfield Agitation Inventory score (MD: -3.12, 95% CI: -8.05, 1.82, I = 0%), Neuropsychiatric Inventory score, sleep efficiency, total sleep time, and Sleep Disorders Inventory score between the groups. Our systematic review and meta-analysis showed that phototherapy significantly improved cognitive function in patients with dementia.
本研究旨在探究光疗干预对老年痴呆症患者认知功能的影响。我们检索了 PubMed、Ovid MEDLINE、Web of Science、EMBASE、Cochrane 中央对照试验注册库、PsycINFO 和临床试验，时间从建库至 2022 年 8 月 10 日，以纳入接受光疗干预的痴呆症患者的随机对照试验。我们使用加权均数差（MD）或标准化均数差来计算合并估计值。主要结局是采用简易精神状态检查（MMSE）评分评估的认知功能。次要结局是行为和心理症状的痴呆（BPSD）和睡眠。本系统评价和荟萃分析已在 PROSPERO（注册号：CRD42022343788）注册。我们纳入了 12 项随机对照试验，共纳入 766 例痴呆症患者（干预组 426 例，对照组 340 例）。光疗干预可显著改善 MMSE 评分（n = 3，MD 2.68，95%置信区间 [CI]：1.38-3.98，I² = 0%）。两组间痴呆症的科恩-曼斯菲尔德激越量表评分、柯恩-曼斯菲尔德激越量表评分（MD：-3.12，95%CI：-8.05，1.82，I² = 0%）、神经精神问卷评分、睡眠效率、总睡眠时间和睡眠障碍量表评分无显著差异。我们的系统评价和荟萃分析表明，光疗可显著改善痴呆症患者的认知功能。
