Liu Chuen-Ru, Liou Yiing Mei, Jou Jwo-Huei
College of Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Psychiatric Nurse of City Hospital, Songde Branch, Taipei, Taiwan.
Front Psychol. 2021 Dec 24;12:782160. doi: 10.3389/fpsyg.2021.782160. eCollection 2021.
Light therapy potentially improves dementia symptoms. In this study, we examined the effects of bright light therapy on neuropsychiatric behaviors and cognitive function. Thirty-five participants were assigned to either the experimental or comparison group. The experimental group was exposed to bright light at 2,500 lux, and the comparison group was exposed to 114-307 lux. The instruments used were the Neuropsychiatric Inventory and the Mini-Mental State Examination. The experimental group showed a significant improvement in Neuropsychiatric Inventory scores; these scores, which were calculated using generalized estimating equations with medication (benzodiazepines) as a covariate, were reduced by 65% < 0.001) and 78% ( = 0.001) by the 5th and 9th weeks, respectively. At the same time, Mini-Mental State Examination scores increased by 19% ( = 0.007) and 28% ( = 0.04), respectively. However, differences in outcomes between the 5th and 9th weeks were not significant. A 4-week regimen of bright light therapy was the most effective, with higher adherence and acceptability.
光疗法可能改善痴呆症状。在本研究中，我们考察了强光疗法对神经精神行为和认知功能的影响。35名参与者被分配到实验组或对照组。实验组暴露于2500勒克斯的强光下，对照组暴露于114 - 307勒克斯的光线下。所使用的工具为神经精神科问卷和简易精神状态检查表。实验组的神经精神科问卷得分有显著改善；这些得分以使用药物（苯二氮䓬类）作为协变量的广义估计方程计算，在第5周和第9周时分别降低了65%（P < 0.001）和78%（P = 0.001）。同时，简易精神状态检查表得分分别提高了19%（P = 0.007）和28%（P = 0.04）。然而，第5周和第9周的结果差异并不显著。为期4周的强光疗法方案最为有效，依从性和可接受性更高。
