通过氢化物转移引发的交叉脱氢偶联反应构建九元环。
Hydride Transfer-Initiated Cross-Dehydrogenative Coupling Reaction to Access Nine-Membered Rings.
作者信息
An Xiao-De, Shao Da-Ying, Qiu Bin, Xiao Jian
机构信息
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China.
出版信息
Org Lett. 2023 Apr 14;25(14):2432-2437. doi: 10.1021/acs.orglett.3c00193. Epub 2023 Apr 5.
PMID:37017104
Abstract
An unprecedented hydride transfer-triggered cross-dehydrogenative coupling of two C(sp)-H bonds to target nine-membered rings has been developed. Salient features of this methodology include atom and step economy and metal-free and redox-neutral conditions, with water as the byproduct and proceeding well even with decomposed aldehydes.
摘要
一种前所未有的由氢化物转移引发的两个C(sp)-H键的交叉脱氢偶联反应已被开发出来，用于构建九元环。该方法的显著特点包括原子经济性和步骤经济性、无金属和氧化还原中性条件，以水作为副产物，并且即使使用分解的醛也能顺利进行。
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