通过碳正离子引发的级联[1,5]-氢化物转移/环化实现的有机催化 C(sp3)-H 功能化：二氢二苯并[b,e]氮杂卓的合成。
Organocatalytic C(sp)-H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]azepines.
机构信息
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University , Qingdao 266109, China.
出版信息
Org Lett. 2018 Jan 5;20(1):138-141. doi: 10.1021/acs.orglett.7b03492. Epub 2017 Dec 14.
PMID:29239184
Abstract
Carbocation-initiated cascade [1,5]-hydride transfer/cyclization and dimerization reactions were developed to synthesize dihydrodibenzo[b,e]azepine and octahydrodipyrroloquinoline derivatives in high yields. These redox-neutral C(sp)-H functionalization-involving cascade reactions feature transition-metal-free, high atom- and step-economy, and environmental friendliness with water as the sole byproduct.
摘要
发展了碳正离子引发的级联[1,5]-氢转移/环化和二聚反应，以高产率合成二氢二苯并[b,e]氮杂卓和八氢二吡咯并喹啉衍生物。这些涉及 C(sp)-H 功能化的无过渡金属、高原子经济性和步骤经济性的氧化还原中性级联反应具有环境友好性，以水为唯一的副产物。
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