Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Chronobiol Int. 2023 May;40(5):653-660. doi: 10.1080/07420528.2023.2197063. Epub 2023 Apr 5.
Bipolar disorder (BD) is a common mental condition with a seasonal pattern (SP) of onset. In the spring, there is a higher incidence rate of mania or mixed onset and suicide. However, the underlying mechanism of this SP remains unclear. In this study, targeted metabolomics was used to understand metabolic changes in patients with BD before and after the spring equinox. Nine patients with BD and matched healthy controls were tested for serum metabolomics at the spring equinox and 15 days before and after the spring equinox. The results showed that 27 metabolite levels changed significantly, three of which interacted between three time points and groups involving triglyceride (TG, 20:4_34:2), TG (20:4_34:3) and TG (16:0_36:6). The identified metabolic pathways mainly involved arginine biosynthesis, D-glutamine and D-glutamate metabolism, and nitrogen metabolism. Changes in solar radiation and lunar cycle during spring may be the external causes of metabolic changes. These findings help to further explore seasonal metabolic changes in patients with BD and provide insights into the mechanisms of patients' emotional changes in spring.
双相情感障碍（BD）是一种常见的精神疾病，具有季节性发病模式（SP）。在春季，躁狂或混合发作和自杀的发病率较高。然而，这种 SP 的潜在机制尚不清楚。在这项研究中，我们使用靶向代谢组学来了解春分前后 BD 患者的代谢变化。在春分和春分前 15 天，对 9 名 BD 患者和匹配的健康对照者进行血清代谢组学检测。结果表明，有 27 种代谢物水平发生了显著变化，其中三种代谢物在三个时间点和涉及甘油三酯（TG，20:4_34:2）、甘油三酯（20:4_34:3）和甘油三酯（16:0_36:6）的两组之间相互作用。鉴定出的代谢途径主要涉及精氨酸生物合成、D-谷氨酰胺和 D-谷氨酸代谢以及氮代谢。春季期间太阳辐射和月相变化可能是代谢变化的外在原因。这些发现有助于进一步探索 BD 患者季节性代谢变化，并深入了解患者春季情绪变化的机制。
