与双相障碍患者非自杀性自伤相关的代谢组学生物标志物。
Metabolomic biomarkers related to non-suicidal self-injury in patients with bipolar disorder.
机构信息
Department of Forensic Medicine, Shanxi Medical University, Taiyuan, China.
Department of Psychiatry, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, 99 Longcheng street, Taiyuan, 030032, Shanxi, China.
出版信息
BMC Psychiatry. 2022 Jul 22;22(1):491. doi: 10.1186/s12888-022-04079-8.
BACKGROUND
Non-suicidal self-injury (NSSI) is an important symptom of bipolar disorder (BD) and other mental disorders and has attracted the attention of researchers lately. It is of great significance to study the characteristic markers of NSSI. Metabolomics is a relatively new field that can provide complementary insights into data obtained from genomic, transcriptomic, and proteomic analyses of psychiatric disorders. The aim of this study was to identify the metabolic pathways associated with BD with NSSI and assess important diagnostic and predictive indices of NSSI in BD.
METHOD
Nuclear magnetic resonance spectrometry was performed to evaluate the serum metabolic profiles of patients with BD with NSSI (n = 31), patients with BD without NSSI (n = 46), and healthy controls (n = 10). Data were analyzed using an Orthogonal Partial Least Square Discriminant Analysis and a t-test. Differential metabolites were identified (VIP > 1 and p < 0.05), and further analyzed using Metabo Analyst 3.0 to identify associated metabolic pathways.
RESULTS
Eight metabolites in the serum and two important metabolic pathways, the urea and glutamate metabolism cycles, were found to distinguish patients with BD with NSSI from healthy controls. Eight metabolites in the serum, glycine and serine metabolism pathway, and the glucose-alanine cycle were found to distinguish patients with BD without NSSI from healthy controls. Five metabolites in the serum and the purine metabolism pathway were found to distinguish patients with BD with NSSI from those with BD without NSSI.
CONCLUSIONS
Abnormalities in the urea cycle, glutamate metabolism, and purine metabolism played important roles in the pathogenesis of BD with NSSI.
背景
非自杀性自伤（NSSI）是双相障碍（BD）和其他精神障碍的一个重要症状，最近引起了研究人员的关注。研究 NSSI 的特征标志物具有重要意义。代谢组学是一个相对较新的领域，可以为精神疾病的基因组、转录组和蛋白质组分析提供补充见解。本研究旨在确定与 NSSI 相关的 BD 的代谢途径，并评估 BD 中 NSSI 的重要诊断和预测指标。
方法
采用核磁共振波谱法对 31 例伴 NSSI 的 BD 患者（NSSI 组）、46 例不伴 NSSI 的 BD 患者（BD 无 NSSI 组）和 10 例健康对照者（对照组）的血清代谢谱进行评估。采用正交偏最小二乘判别分析和 t 检验进行数据分析。鉴定差异代谢物（VIP>1 和 p<0.05），并进一步使用 Metabo Analyst 3.0 分析鉴定相关代谢途径。
结果
发现血清中 8 种代谢物和 2 个重要代谢途径，即尿素和谷氨酸代谢循环，可将伴 NSSI 的 BD 患者与健康对照者区分开来。血清中 8 种代谢物、甘氨酸和丝氨酸代谢途径以及葡萄糖-丙氨酸循环可将不伴 NSSI 的 BD 患者与健康对照者区分开来。血清中 5 种代谢物和嘌呤代谢途径可将伴 NSSI 的 BD 患者与不伴 NSSI 的 BD 患者区分开来。
结论
尿素循环、谷氨酸代谢和嘌呤代谢异常在伴 NSSI 的 BD 发病机制中发挥重要作用。
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