Dhakal A, Pokharel M, Madhup S, Khadka L, Sapkota B
Department of ENT-HNS, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre, Nepal.
Kathmandu Univ Med J (KUMJ). 2022 Apr-Jun;20(78):249-251.
Coronavirus disease 2019 (COVID-19) is a pandemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). COVID-19 infections may be associated with a wide range of bacterial and fungal co-infections. Recent studies are reporting invasive fungal infection associated with severe COVID-19. Herein, we report a case of COVID-19 rhino-orbital mucormycosis infection caused by Rhizopus sps in a 32 year old diabetic patient who was successfully managed with early aggressive debridement of infected tissue endoscopically with extended ethmoidectomy by modified Denker's approach along with orbital decompression and antifungal therapy with Liposomal Amphotericin B and Posaconazole. Serial diagnostic nasal endoscopy showed no evidence of progression of the infection. The patient was discharged on 21st day of hospitalization still on oral Posaconazole for a total of 3 months.
2019冠状病毒病（COVID-19）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的一种大流行性疾病。COVID-19感染可能与多种细菌和真菌合并感染有关。最近的研究报告了与严重COVID-19相关的侵袭性真菌感染。在此，我们报告一例由根霉属引起的COVID-19鼻眶毛霉菌病感染病例，该患者为一名32岁的糖尿病患者，通过改良Denker法进行扩大筛窦切除术并结合眼眶减压，在内镜下对感染组织进行早期积极清创，同时使用脂质体两性霉素B和泊沙康唑进行抗真菌治疗，成功治愈。系列诊断性鼻内镜检查显示感染无进展迹象。患者在住院第21天出院，仍口服泊沙康唑共3个月。
