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COVID-19 合并糖尿病患者中由微小毛霉变种微小毛霉引起的鼻眶脑毛霉病。

Rhino-orbito-cerebral mucormycosis caused by Rhizopus microsporus var. microsporus in a diabetic patient with COVID-19.

机构信息

Dermatology Clinic, Hospital da Santa Casa de São Paulo, São Paulo, SP, Brazil.

Pathology Laboratory, Hospital da Santa Casa de São Paulo, São Paulo, SP, Brazil.

出版信息

An Bras Dermatol. 2022 Jul-Aug;97(4):501-504. doi: 10.1016/j.abd.2022.02.001. Epub 2022 Jun 9.

Abstract

COVID-19 disease caused by the SARS-CoV-2 coronavirus causes a wide range of clinical manifestations, ranging from mild to severe, with the main ones affecting the respiratory tract, such as pneumonia. In patients with greater severity, the high frequency of bacterial and fungal coinfection stands out, a situation related both to the patient's pre-existing comorbidities and due to the hospitalization itself. Cases of mucormycosis associated with COVID-19 were highlighted in the lay and scientific media, with the increase in mycosis cases being directly and indirectly attributed to the viral infection. This report describes a case of rhino-orbito-cerebral mucormycosis in a diabetic patient hospitalized for COVID-19, whose diagnosis was confirmed by identifying the agent Rhizopus microsporus var. microsporus through culture for fungi and PCR examination.

摘要

由严重急性呼吸综合征冠状病毒 2 型(SARS-CoV-2)引起的 COVID-19 疾病可引起广泛的临床表现,从轻症到重症不等,主要影响呼吸道,如肺炎。在病情较重的患者中,细菌和真菌感染的频率很高,这种情况既与患者的既往合并症有关,也与住院本身有关。COVID-19 相关的毛霉菌病病例在大众和科学媒体中受到关注,真菌感染病例的增加直接或间接归因于病毒感染。本报告描述了一例因 COVID-19 住院的糖尿病患者发生的鼻-眶-脑毛霉菌病,通过真菌培养和 PCR 检查鉴定出病原体微小根毛霉微小变种,从而确诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/883a/9263668/305b60f6ebf8/gr1.jpg

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