乳糜泻与溃疡性结肠炎的家族关联：初步交流。
Familial association between coeliac disease and ulcerative colitis: preliminary communication.
作者信息
Mayberry J F, Smart H L, Toghill P J
出版信息
J R Soc Med. 1986 Apr;79(4):204-5. doi: 10.1177/014107688607900405.
One hundred and twenty patients who were members of the Nottinghamshire Coeliac Group completed a questionnaire about the occurrence of coeliac disease, ulcerative colitis and Crohn's disease amongst first-degree relatives. Siblings were at a 20-fold risk of developing coeliac disease and a 15-fold risk of developing ulcerative colitis, and significantly increased risks for these two conditions were also seen in other family members. The relatives of patients with coeliac disease are at increased risk not only of developing coeliac disease but also ulcerative colitis. This provides further support for a possible role of a dietary allergen in the development of ulcerative colitis.
120名诺丁汉郡乳糜泻患者小组的成员完成了一份关于一级亲属中乳糜泻、溃疡性结肠炎和克罗恩病发病情况的调查问卷。兄弟姐妹患乳糜泻的风险是常人的20倍，患溃疡性结肠炎的风险是常人的15倍，其他家庭成员患这两种疾病的风险也显著增加。乳糜泻患者的亲属不仅患乳糜泻的风险增加，患溃疡性结肠炎的风险也增加。这进一步支持了饮食过敏原在溃疡性结肠炎发病过程中可能发挥的作用。
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