eccDB：一个多物种中外显子环 DNA 介导的染色质接触的综合数据库。
eccDB: a comprehensive repository for eccDNA-mediated chromatin contacts in multi-species.
机构信息
Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China.
Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China.
出版信息
Bioinformatics. 2023 Apr 3;39(4). doi: 10.1093/bioinformatics/btad173.
SUMMARY
We developed the eccDB database to integrate available resources for extrachromosomal circular DNA (eccDNA) data. eccDB is a comprehensive repository for storing, browsing, searching, and analyzing eccDNAs from multispecies. The database provides regulatory and epigenetic information on eccDNAs, with a focus on analyzing intrachromosomal and interchromosomal interactions to predict their transcriptional regulatory functions. Moreover, eccDB identifies eccDNAs from unknown DNA sequences and analyzes the functional and evolutionary relationships of eccDNAs among different species. Overall, eccDB offers web-based analytical tools and a comprehensive resource for biologists and clinicians to decipher the molecular regulatory mechanisms of eccDNAs.
AVAILABILITY AND IMPLEMENTATION
eccDB is freely available at http://www.xiejjlab.bio/eccDB.
摘要
我们开发了 eccDB 数据库，用于整合可用于外染色体环状 DNA（eccDNA）数据的资源。eccDB 是一个用于存储、浏览、搜索和分析来自多物种的 eccDNA 的综合存储库。该数据库提供了关于 eccDNA 的调控和表观遗传信息，重点分析了染色内和染色间相互作用，以预测它们的转录调控功能。此外，eccDB 还可以从未知的 DNA 序列中识别 eccDNA，并分析不同物种之间 eccDNA 的功能和进化关系。总的来说，eccDB 提供了基于网络的分析工具和一个全面的资源，供生物学家和临床医生破译 eccDNA 的分子调控机制。
可用性和实现
eccDB 可免费在 http://www.xiejjlab.bio/eccDB 上获取。
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