正常细胞和肿瘤细胞中外源环状 DNA 的发现。
Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells.
机构信息
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
出版信息
Trends Genet. 2018 Apr;34(4):270-278. doi: 10.1016/j.tig.2017.12.010. Epub 2018 Jan 9.
While the vast majority of cellular DNA in eukaryotes is contained in long linear strands in chromosomes, we have long recognized some exceptions like mitochondrial DNA, plasmids in yeasts, and double minutes (DMs) in cancer cells where the DNA is present in extrachromosomal circles. In addition, specialized extrachromosomal circles of DNA (eccDNA) have been noted to arise from repetitive genomic sequences like telomeric DNA or rDNA. Recently eccDNA arising from unique (nonrepetitive) DNA have been discovered in normal and malignant cells, raising interesting questions about their biogenesis, function and clinical utility. Here, we review recent results and future directions of inquiry on these new forms of eccDNA.
虽然真核生物细胞中的绝大多数 DNA 都包含在染色体的长线性链中，但我们早就认识到一些例外，如线粒体 DNA、酵母中的质粒以及癌细胞中的双微体（DMs），这些 DNA 以染色体外的环状存在。此外，已经注意到来自端粒 DNA 或 rDNA 等重复基因组序列的专门染色体外 DNA （eccDNA）。最近，在正常和恶性细胞中发现了来自独特（非重复）DNA 的 eccDNA，这引发了关于它们的发生、功能和临床应用的有趣问题。在这里，我们回顾了这些新型 eccDNA 的最新研究结果和未来研究方向。
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