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[一名有肝移植病史的患者因艰难梭菌感染导致暴发性结肠炎:一种严重的危及生命的并发症]

[Fulminant colitis due to Clostridium Difficile in a patient with a history of liver transplantation: a severe life-threatening complication].

作者信息

Sultano Nicolas, Gonzalez Salazar Esteban, Poggi Catalina, Higuera Felipe, Pekolj Juan

机构信息

HOSPITAL ITALIANO DE BUENOS AIRES ARGENTINA.

出版信息

Rev Fac Cien Med Univ Nac Cordoba. 2023 Apr 5;80(1):43-46. doi: 10.31053/1853.0605.v80.n1.37579.

DOI:10.31053/1853.0605.v80.n1.37579
PMID:37018358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10142679/
Abstract

Clostridium difficile´s fulminant colitis is characterized by the development of severe acute inflammation of the colon, associated with systemic toxicity. Fulminant colitis is the most serious form of acute colitis with a mortality of up to 80%. We present the case of a 45-year-old man who presented to the emergency department with acute abdominal pain, diarrhea and fever. Computed tomography showed circumferential diffuse parietal thickening of the colon, including the rectum, associated with striation of the surrounding tissues and ganglionic formations. In the following hours the patient evolved with worsening of the general condition, increased inotropic requirements and lactic acidosis. Emergency laparotomy was decided and total colectomy was performed. Fulminant Clostridium difficile colitis is a potentially deadly disease. The lability of the pathology in many occasions forces quick decision making, therefore fulminant colitis represents a medical surgical emergency being time crucial.

摘要

艰难梭菌性暴发性结肠炎的特征是结肠出现严重急性炎症,并伴有全身毒性。暴发性结肠炎是急性结肠炎最严重的形式,死亡率高达80%。我们报告一例45岁男性病例,该患者因急性腹痛、腹泻和发热就诊于急诊科。计算机断层扫描显示结肠(包括直肠)周向弥漫性肠壁增厚,伴有周围组织条纹状改变和神经节形成。在接下来的几个小时里,患者的一般状况恶化,对血管活性药物的需求增加,并出现乳酸酸中毒。决定进行急诊剖腹手术并实施全结肠切除术。艰难梭菌性暴发性结肠炎是一种潜在的致命疾病。该病理情况的易变性在很多情况下迫使迅速做出决策,因此暴发性结肠炎是一种外科急症,时间至关重要。

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本文引用的文献

1
Clostridioides difficile infection in solid organ and hematopoietic stem cell transplant recipients: A prospective multinational study.实体器官和造血干细胞移植受者艰难梭菌感染:一项前瞻性多国研究。
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Clostridium difficile Infection.艰难梭菌感染
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Prevalence of Clostridium difficile infection among solid organ transplant recipients: a meta-analysis of published studies.实体器官移植受者中艰难梭菌感染的患病率:已发表研究的荟萃分析
PLoS One. 2015 Apr 17;10(4):e0124483. doi: 10.1371/journal.pone.0124483. eCollection 2015.
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8
Diagnostic yields in solid organ transplant recipients admitted with diarrhea.因腹泻入院的实体器官移植受者的诊断率。
Clin Infect Dis. 2015 Mar 1;60(5):729-37. doi: 10.1093/cid/ciu880. Epub 2014 Nov 3.
9
Fulminant colitis.暴发性结肠炎。
Best Pract Res Clin Gastroenterol. 2013 Oct;27(5):771-82. doi: 10.1016/j.bpg.2013.08.011. Epub 2013 Sep 6.
10
Is colectomy for fulminant Clostridium difficile colitis life saving? A systematic review.暴发性艰难梭菌结肠炎行结肠切除术是否可拯救生命?系统评价。
Colorectal Dis. 2013 Jul;15(7):798-804. doi: 10.1111/codi.12134.