Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.
Cytokine. 2023 Jun;166:156187. doi: 10.1016/j.cyto.2023.156187. Epub 2023 Mar 24.
COVID-19 is associated with dysregulation of several genes and signaling pathways. Based on the importance of expression profiling in identification of the pathogenesis of COVID-19 and proposing novel therapies for this disorder, we have employed an in silico approach to find differentially expressed genes between COVID-19 patients and healthy controls and their relevance with cellular functions and signaling pathways. We obtained 630 DEmRNAs, including 486 down-regulated DEGs (such as CCL3 and RSAD2) and 144 up-regulated DEGs (such as RHO and IQCA1L), and 15 DElncRNAs, including 9 down-regulated DElncRNAs (such as PELATON and LINC01506) and 6 up-regulated DElncRNAs (such as AJUBA-DT and FALEC). The PPI network of DEGs showed the presence of a number immune-related genes such as those coding for HLA molecules and interferon regulatory factors. Taken together, these results highlight the importance of immune-related genes and pathways in the pathogenesis of COVID-19 and suggest novel targets for treatment of this disorder.
COVID-19 与多个基因和信号通路的失调有关。基于表达谱分析在确定 COVID-19 发病机制和为该疾病提出新疗法方面的重要性，我们采用了一种计算方法来寻找 COVID-19 患者和健康对照之间差异表达的基因，以及它们与细胞功能和信号通路的相关性。我们获得了 630 个差异表达的 mRNAs，包括 486 个下调的 DEGs（如 CCL3 和 RSAD2）和 144 个上调的 DEGs（如 RHO 和 IQCA1L），以及 15 个差异表达的 lncRNAs，包括 9 个下调的 DElncRNAs（如 PELATON 和 LINC01506）和 6 个上调的 DElncRNAs（如 AJUBA-DT 和 FALEC）。DEGs 的 PPI 网络显示存在许多免疫相关基因，如编码 HLA 分子和干扰素调节因子的基因。综上所述，这些结果强调了免疫相关基因和通路在 COVID-19 发病机制中的重要性，并为该疾病的治疗提供了新的靶点。
