School of Health and Medical Sciences, University of Southern Queensland, Ipswich, Queensland, Australia; Molecular Biomarkers Research Group, University of Southern Queensland, Toowoomba, Queensland, Australia.
School of Health and Medical Sciences, University of Southern Queensland, Ipswich, Queensland, Australia; Centre for Health Research, Institute for Resilient Regions, University of Southern Queensland, Ipswich, Queensland, Australia; Molecular Biomarkers Research Group, University of Southern Queensland, Toowoomba, Queensland, Australia.
Breast. 2023 Jun;69:358-365. doi: 10.1016/j.breast.2023.03.018. Epub 2023 Mar 31.
Reduced cognition is often reported by breast cancer patients and survivors, but the mechanisms for this decline are yet to be determined. We compared the differences in cerebrovascular function and cognition in breast cancer survivors (n = 15) and cancer-free women (n = 15) matched by age and body mass index. Participants undertook anthropometric, mood, cardiovascular, exercise performance, strength, cerebrovascular, and cognitive measurements. Transcranial Doppler ultrasound was used to measure the cerebrovascular responsiveness (CVR) to physiological (hypercapnia; 5% carbon dioxide) and psychological stimuli. Breast cancer survivors had a lower CVR to hypercapnia (21.5 ± 12.8 vs 66.0 ± 20.9%, P < 0.001), CVR to cognitive stimuli (15.1 ± 1.5 vs 23.7 ± 9.0%, P < 0.001) and total composite cognitive score (100 ± 12 vs. 113 ± 7, P = 0.003) than cancer-free women. These parameters remained statistically different between the groups following adjustments for covariates using an analysis of co-variance. We observed significant correlations between multiple measures and exercise capacity the only variable positively correlated to all primary measures (CVR to hypercapnia, r = 0.492, P = 0.007; CVR to cognitive stimuli r = 0.555, P = 0.003; and total composite cognitive score, r = 0.625, P < 0.001). In this study, breast cancer survivors had lower cerebrovascular and cognitive function than age-matched cancer-free women, which may be attributable to the effects of cancer and cancer treatment on brain health.
乳腺癌患者和幸存者常报告认知能力下降，但这种下降的机制尚未确定。我们比较了 15 例乳腺癌幸存者和 15 例年龄和体重指数匹配的无癌症女性的脑血管功能和认知差异。参与者进行了人体测量、情绪、心血管、运动表现、力量、脑血管和认知测量。经颅多普勒超声用于测量脑血管对生理（高碳酸血症；5%二氧化碳）和心理刺激的反应性（CVR）。乳腺癌幸存者的高碳酸血症 CVR 较低（21.5±12.8 对 66.0±20.9%，P<0.001）、认知刺激的 CVR 较低（15.1±1.5 对 23.7±9.0%，P<0.001）和总综合认知评分较低（100±12 对 113±7，P=0.003）。使用协方差分析对协变量进行调整后，这些参数在两组之间仍然存在统计学差异。我们观察到多个测量值与运动能力之间存在显著相关性，运动能力是唯一与所有主要测量值呈正相关的变量（高碳酸血症 CVR，r=0.492，P=0.007；认知刺激 CVR，r=0.555，P=0.003；和总综合认知评分，r=0.625，P<0.001）。在这项研究中，乳腺癌幸存者的脑血管和认知功能低于年龄匹配的无癌症女性，这可能归因于癌症及其治疗对大脑健康的影响。
