骨髓脂肪细胞衰老：糖皮质激素诱导骨恶化的新线索。
Senescence of bone marrow fat cells: A new clue for glucocorticoid-induced bone deterioration.
机构信息
Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Shenzhen 518055, China.
出版信息
Cell Metab. 2023 Apr 4;35(4):551-553. doi: 10.1016/j.cmet.2023.03.009.
Glucocorticoid (GC)-induced osteoporosis is the most common secondary cause of osteoporosis, resulting in fractures and significant morbidity. In this issue of Cell Metabolism, Liu et al. reveal that in response to GCs, bone marrow adipocytes (BMAds) undergo rapid cellular senescence, triggering secondary senescence in bone marrow and causing bone deterioration.
糖皮质激素（GC）诱导性骨质疏松症是最常见的继发性骨质疏松症，可导致骨折和严重的发病率。在本期《细胞代谢》中，刘等人揭示了 GC 会导致骨髓脂肪细胞（BMAds）快速发生细胞衰老，进而引发骨髓中的继发性衰老，导致骨质恶化。
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